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Comment
. 2022 Mar 31;185(7):1110-1111.
doi: 10.1016/j.cell.2022.03.006.

Locally produced autoantibodies in cancer

Sara M Centuori  1 , Deepta Bhattacharya  2
Affiliations
Free article
Comment

Locally produced autoantibodies in cancer

Sara M Centuori et al. Cell. .
Free article

Abstract

The function and antigen-specificities of tumor-infiltrating B cells are mostly unknown. In a new study by Mazor et al., matrix metalloproteinase 14 (MMP14), a self-antigen that is overexpressed by ovarian cancers, is shown to drive B cell activation and autoantibody production in tertiary lymphoid structures (Mazor et al., 2022).

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Conflict of interest statement

Declaration of interests Sana Biotechnology has licensed intellectual property of D.B. and Washington University in St. Louis. Gilead Sciences has licensed intellectual property of D.B. and Stanford University. D.B. is a co-founder of Clade Therapeutics. D.B. is on an advisory panel for GlaxoSmithKline. S.M.C. has no conflicts of interests.

Comment on

  • Tumor-reactive antibodies evolve from non-binding and autoreactive precursors.
    Mazor RD, Nathan N, Gilboa A, Stoler-Barak L, Moss L, Solomonov I, Hanuna A, Divinsky Y, Shmueli MD, Hezroni H, Zaretsky I, Mor M, Golani O, Sabah G, Jakobson-Setton A, Yanichkin N, Feinmesser M, Tsoref D, Salman L, Yeoshoua E, Peretz E, Erlich I, Cohen NM, Gershoni JM, Freund N, Merbl Y, Yaari G, Eitan R, Sagi I, Shulman Z. Mazor RD, et al. Cell. 2022 Mar 31;185(7):1208-1222.e21. doi: 10.1016/j.cell.2022.02.012. Epub 2022 Mar 18. Cell. 2022. PMID: 35305314

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