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Comment
. 2022 Mar 31;185(7):1112-1114.
doi: 10.1016/j.cell.2022.03.004.

CAR T cells are in it [CD]4 the long haul

Amanda C Poholek  1
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Free article
Comment

CAR T cells are in it [CD]4 the long haul

Amanda C Poholek. Cell. .
Free article

Abstract

In a recent issue of Nature, Melenhorst et al. perform an extensive analysis of CAR T cells that persist for ten years in CLL patients. They find a dominant cytotoxic CD4+ population, raising the possibility that CD4+ T cells play an important role in durable CAR T cell therapy.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

Comment on

  • Decade-long leukaemia remissions with persistence of CD4+ CAR T cells.
    Melenhorst JJ, Chen GM, Wang M, Porter DL, Chen C, Collins MA, Gao P, Bandyopadhyay S, Sun H, Zhao Z, Lundh S, Pruteanu-Malinici I, Nobles CL, Maji S, Frey NV, Gill SI, Loren AW, Tian L, Kulikovskaya I, Gupta M, Ambrose DE, Davis MM, Fraietta JA, Brogdon JL, Young RM, Chew A, Levine BL, Siegel DL, Alanio C, Wherry EJ, Bushman FD, Lacey SF, Tan K, June CH. Melenhorst JJ, et al. Nature. 2022 Feb;602(7897):503-509. doi: 10.1038/s41586-021-04390-6. Epub 2022 Feb 2. Nature. 2022. PMID: 35110735 Free PMC article.

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