Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr 1.
doi: 10.1245/s10434-022-11581-6. Online ahead of print.

Impact of Screening Mammography on Treatment in Young Women Diagnosed with Breast Cancer

Shkala Karzai  1 , Elisa Port  1 , Cleo Siderides  1 , Christopher Valente  1 , Soojin Ahn  1 , Erin Moshier  1 , Meng Ru  1 , Kereeti Pisapati  1 , Ronald Couri  1 , Laurie Margolies  1 , Hank Schmidt  1 , Sarah Cate  2
Affiliations

Impact of Screening Mammography on Treatment in Young Women Diagnosed with Breast Cancer

Shkala Karzai et al. Ann Surg Oncol. .

Abstract

Background: There is little data exploring the impact of screening mammography on subsequent treatment in the 40-49-year age group with breast cancer. We sought to assess the association between frequency of mammography in young women and extent of surgery and chemotherapy required.

Methods: An IRB-approved retrospective review was performed of patients diagnosed with breast cancer between ages 40 and 49 years from 1 January 2010 to 19 November 2018 within a single health system. Patients were grouped based on last screening 1-24 months prior to diagnosis (1-24 group), > 25 months prior to diagnosis (> 25 group), never screened, and > 25+ never screened (combination group). Multivariate logistic regression models were used to assess for associations between screening intervals and tumor and nodal stage, chemotherapy use, and extent of surgery.

Results: Of 869 patients included for analysis, 20% were never screened, 60% screened 1-24 months, and 19% screened > 25 months prior to diagnosis. Compared with the 1-24 months group, the never-screened group, > 25 months group, and combined group were more likely to receive chemotherapy. The never-screened and combined groups were more likely to undergo mastectomy and/or axillary lymph node dissection. Of patients undergoing upfront surgery, the > 25 months and combined groups were more likely to receive adjuvant chemotherapy, while the never-screened and combined groups were more likely to have nodal disease.

Conclusion: Our findings support the initiation of screening mammography at age 40 years to reduce the risk of aggressive treatments for newly diagnosed breast cancers in this group.

PubMed Disclaimer

References

    1. Cancer Statistics 2019: About Breast Cancer. American Cancer Society. https://www.cancer.org/content/dam/CRC/PDF/Public/8577.00.pdf . Accessed 3 Jan 2020.
    1. National Cancer Institute Surveillance E, and End Results Program Cancer Stat Facts: Female Breast Cancer https://seer.cancer.gov/statfacts/html/breast.html . Accessed 3 Jan 2020
    1. Alexander FE, Anderson TJ, Brown HK, et al. 14 years of follow-up from the Edinburgh randomised trial of breast-cancer screening. Lancet. 1999;353(9168):1903–8. - DOI
    1. Andersson I, Aspegren K, Janzon L, et al. Mammographic screening and mortality from breast cancer: the Malmo mammographic screening trial. BMJ. 1988;297(6654):943–8. - DOI
    1. Bjurstam N, Bjorneld L, Duffy SW, et al. The gothenburg breast cancer screening trial: preliminary results on breast cancer mortality for women aged 39–49. J Natl Cancer Inst Monogr. 1997;1997(22):53–5. - DOI

LinkOut - more resources