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. 2022 Jul;107(7):674-680.
doi: 10.1136/archdischild-2021-323624. Epub 2022 Apr 1.

Long COVID (post-COVID-19 condition) in children: a modified Delphi process

Terence Stephenson  1 , Benjamin Allin  2 , Manjula D Nugawela  3 , Natalia Rojas  3 , Emma Dalrymple  3 , Snehal Pinto Pereira  4 , Manas Soni  5 , Marian Knight  2 , Emily Y Cheung  3 , Isobel Heyman  3 ; CLoCk Consortium; Roz Shafran  3
Collaborators, Affiliations

Long COVID (post-COVID-19 condition) in children: a modified Delphi process

Terence Stephenson et al. Arch Dis Child. 2022 Jul.

Abstract

Objective: The aim of this study was to derive a research definition for 'Long COVID (post-COVID-19 condition)' in children and young people (CYP) to allow comparisons between research studies.

Design: A three-phase online Delphi process was used, followed by a consensus meeting. Participants were presented with 49 statements in each phase and scored them from 1 to 9 based on how important they were for inclusion in the research definition of Long COVID in CYP. The consensus meeting was held to achieve representation across the stakeholder groups. Statements agreed at the consensus meeting were reviewed by participants in the Patient and Public Involvement (PPI) Research Advisory Group.

Setting: The study was conducted remotely using online surveys and a virtual consensus meeting.

Participants: 120 people with relevant expertise were divided into three panels according to their area of expertise: Service Delivery, Research (or combination of research and service delivery) and Lived Experience. The PPI Research Advisory group consisted of CYP aged 11-17 years.

Main outcome measures: Consensus was defined using existing guidelines. If consensus was achieved in two or more panels or was on the border between one and two panels, those statements were discussed and voted on at the consensus meeting.

Results: Ten statements were taken forward for discussion in the consensus meeting and five statements met threshold to be included in the research definition of Long COVID among CYP. The research definition, aligned to the clinical case definition of the WHO, is proposed as follows: Post-COVID-19 condition occurs in young people with a history of confirmed SARS-CoV-2 infection, with at least one persisting physical symptom for a minimum duration of 12 weeks after initial testing that cannot be explained by an alternative diagnosis. The symptoms have an impact on everyday functioning, may continue or develop after COVID infection, and may fluctuate or relapse over time. The positive COVID-19 test referred to in this definition can be a lateral flow antigen test, a PCR test or an antibody test.

Conclusions: This is the first research definition of Long COVID (post-COVID-19 condition) in CYP and complements the clinical case definition in adults proposed by the WHO.

Keywords: COVID-19; adolescent health; child health.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Consensus process. CYP, children and young people.
See this image and copyright information in PMC

References

    1. Stephenson T, Pereira SP, Shafran R. Long COVID - the physical and mental health of children and non-hospitalised young people 3 months after SARS-CoV-2 infection; a national matched cohort study (The CLoCk) Study 2021.
    1. Molteni E, Sudre CH, Canas LS, et al. . Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2. Lancet Child Adolesc Health 2021;5:708–18. 10.1016/S2352-4642(21)00198-X - DOI - PMC - PubMed
    1. Sudre CH, Murray B, Varsavsky T, et al. . Attributes and predictors of long COVID. Nat Med 2021;27:626–31. 10.1038/s41591-021-01292-y - DOI - PMC - PubMed
    1. Davis HE, Assaf GS, McCorkell L, et al. . Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine 2021;38:101019. 10.1016/j.eclinm.2021.101019 - DOI - PMC - PubMed
    1. Amin-Chowdhury Z, Ladhani SN. Causation or confounding: why controls are critical for characterizing long COVID. Nat Med 2021;27:1129–30. 10.1038/s41591-021-01402-w - DOI - PubMed

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