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. 2022 Sep;42(9):2939-2947.
doi: 10.1007/s10792-022-02282-w. Epub 2022 Apr 2.

Anterior segment structures in dark iris Chinese patients with unilateral Fuchs' uveitis syndrome

Yajing Cai  1 , Wenjie Wu  2   3 , Yingbin Wang  1 , Suzhen Xiao  1 , Yue Huang  1
Affiliations

Anterior segment structures in dark iris Chinese patients with unilateral Fuchs' uveitis syndrome

Yajing Cai et al. Int Ophthalmol. 2022 Sep.

Abstract

Purpose: To compare binocular anterior segment structures in Chinese patients with dark iris and unilateral Fuchs' uveitis syndrome (FUS).

Methods: This was a cross-sectional study including 34 phakic eyes (17 patients) with unilateral FUS. Anterior segment parameters were measured by rotating Scheimpflug imaging camera, noncontact specular microscopy, and anterior segment optical coherence tomography.

Results: Corneal volume was higher in FUS eyes compared to unaffected eyes (p < 0.05). The iridocorneal angles were larger in FUS eyes compared to contralateral eyes (p < 0.05). Mean endothelial cell density (ECD) was lower, and the coefficient of variation in endothelial cell size and average cell area of endothelial cells (ACA) were higher, in FUS eyes (p < 0.05). Mean densitometry values of the midstromal cornea (zones with a diameter of 0-2, 2-6, or 10-12 mm), posterior (0-2, 2-6, 10-12, or 0-12 mm), or total thickness (0-2 or 2-6 mm) were higher in FUS eyes compared with unaffected eyes (p < 0.05). ECD, percentage of hexagonal cells, and ACA were strongly related to densitometry values of the midstromal and posterior cornea in the FUS eyes (p < 0.05). Smoothness index of iris was lager in affected eyes (p < 0.05).

Conclusion: In Chinese patients with unilateral FUS, loss of endothelial cells, wider iridocorneal angle, thicker cornea, higher corneal densitometry of midstromal and posterior layer, and smoother iris were observed in affected eyes compared to contralateral eyes. These data can help to elucidate anterior segment characteristics of unilateral FUS in this population.

Keywords: Anterior segment structure; Chinese patients; Dark iris; Fuchs; Uveitis syndrome.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Smoothness Index (SI); ratio of the length of the straight line connecting the most peripheral and the most central points of anterior iris surface (b) to actual length of this boundary (a). Overall SI is the sum length of nasal and temporal “straight lines” divided by the sum of nasal and temporal actual lengths of anterior iris boundary
Fig. 2
Fig. 2
Anterior segment image of a unilateral FUS patient. The many hyper-reflective points correspond to KPs on the inner surface of the cornea in the affected (left) eye. At the top is the unaffected eye and at the bottom is the FUS eye
See this image and copyright information in PMC

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