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Review
. 2022 Jun;41(2):317-331.
doi: 10.1007/s10555-022-10022-w. Epub 2022 Apr 2.

Connecting the Human Microbiome and Pancreatic Cancer

Rachel E Sexton  1 , Md Hafiz Uddin  1 , Sahar Bannoura  1 , Husain Yar Khan  1 , Yousef Mzannar  1 , Yiwei Li  1 , Amro Aboukameel  1 , Mohammad Najeeb Al-Hallak  1 , Bayan Al-Share  1 , Amr Mohamed  2   3 , Misako Nagasaka  4 , Bassel El-Rayes  5 , Asfar S Azmi  6
Affiliations
Review

Connecting the Human Microbiome and Pancreatic Cancer

Rachel E Sexton et al. Cancer Metastasis Rev. 2022 Jun.

Erratum in

  • Correction to: Connecting the human microbiome and pancreatic cancer.
    Sexton RE, Uddin MH, Bannoura S, Khan HY, Mzannar Y, Li Y, Aboukameel A, Al-Hallak MN, Al-Share B, Mohamed A, Nagasaka M, El-Rayes B, Azmi AS. Sexton RE, et al. Cancer Metastasis Rev. 2022 Jun;41(2):333. doi: 10.1007/s10555-022-10037-3. Cancer Metastasis Rev. 2022. PMID: 35536453 Free PMC article. No abstract available.

Abstract

Pancreatic cancer is a deadly disease that is increasing in incidence throughout the world. There are no clear causal factors associated with the incidence of pancreatic cancer; however, some correlation to smoking, diabetes and alcohol has been described. Recently, a few studies have linked the human microbiome (oral and gastrointestinal tract) to pancreatic cancer development. A perturbed microbiome has been shown to alter normal cells while promoting cancer-related processes such as increased cell signaling, immune system evasion and invasion. In this article, we will review in detail the alterations within the gut and oral microbiome that have been linked to pancreatic cancer and explore the ability of other microbiomes, such as the lung and skin microbiome, to contribute to disease development. Understanding ways to identify a perturbed microbiome can result in advancements in pancreatic cancer research and allow for prevention, earlier detection and alternative treatment strategies for patients.

Keywords: Human Microbiome; Oncogenesis; Pancreatic Cancer.

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Conflict of interest statement

ASA received funding from Karyopharm, EISAI, Jannsen and Rhizen. ASA received speaker fees from Karyopharm Therapeutics Inc. ASA is a council member at GLG and Guidepoint.

Figures

Fig. 1
Fig. 1
Overall Scheme of the Human Microbiome in Relation to Pancreatic Cancer
See this image and copyright information in PMC

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