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. 2021 Nov 3;28(4):496-500.
doi: 10.3390/pathophysiology28040032.

The Usefulness of Rare Blood Group Systems in the Risk Determination for Severe COVID-19

Theocharis G Konstantinidis  1   2 , Valeria Iliadi  3 , Georges Martinis  1 , Maria Panopoulou  2
Affiliations

The Usefulness of Rare Blood Group Systems in the Risk Determination for Severe COVID-19

Theocharis G Konstantinidis et al. Pathophysiology. .

Abstract

The newly identified human coronavirus was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on a detailed analysis of clinical manifestation. It was reported that blood type O individuals were less likely to become infected by SARS-CoV, while blood type A individuals have an increased risk of severe illness. The Forssman antigen, or Forssman glycolipid synthase (FS), was first described in 1911 by John Frederick Forssman. Blood type A/B glycosyltransferases (AT/BTs) and Forssman glycolipid synthase (FS) are encoded by the evolutionarily related ABO (A/B alleles) and GBGT1 genes. In this article, based on published studies about the pathogenesis of the COVID-19, we hypothesize the possible relationship between the COVID-19 infection and rare blood type systems, such as the Forssman antigen system.

Keywords: COVID-19; Forssman antigen; blood type.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Gorbalenya A.E., Baker S.C., Baric R.S., de Groot R.J., Drosten C., Gulyaeva A.A., Haagmans B.L., Lauber C., Leontovich A.M., Neuman B.W., et al. The Species Severe Acute Respiratory Syndrome-Related Coronavirus: Classifying 2019-NCoV and Naming It SARS-CoV-2. Nat. Microbiol. 2020;5:536–544. doi: 10.1038/s41564-020-0695-z. - DOI - PMC - PubMed
    1. Weiss S.R. Forty Years with Coronaviruses. J. Exp. Med. 2020;217 doi: 10.1084/jem.20200537. - DOI - PMC - PubMed
    1. Wu A., Peng Y., Huang B., Ding X., Wang X., Niu P., Meng J., Zhu Z., Zhang Z., Wang J., et al. Genome Composition and Divergence of the Novel Coronavirus (2019-NCoV) Originating in China. Cell Host Microbe. 2020;27:325–328. doi: 10.1016/j.chom.2020.02.001. - DOI - PMC - PubMed
    1. Masters P.S. The Molecular Biology of Coronaviruses. Adv. Virus Res. 2006;66:193–292. doi: 10.1016/S0065-3527(06)66005-3. - DOI - PMC - PubMed
    1. Lan J., Ge J., Yu J., Shan S., Zhou H., Fan S., Zhang Q., Shi X., Wang Q., Zhang L., et al. Structure of the SARS-CoV-2 Spike Receptor-Binding Domain Bound to the ACE2 Receptor. Nature. 2020;581:215–220. doi: 10.1038/s41586-020-2180-5. - DOI - PubMed

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