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Review
. 2022 May;27(3):189-195.
doi: 10.1007/s12192-022-01269-x. Epub 2022 Apr 3.

Neutralizing the free radicals could alleviate the disease severity following an infection by positive strand RNA viruses

Agieshkumar Balakrishna Pillai  1 , Aashika Raagavi JeanPierre  2 , Vignesh Mariappan  2 , Pajanivel Ranganadin  3 , Rao S R  4
Affiliations
Review

Neutralizing the free radicals could alleviate the disease severity following an infection by positive strand RNA viruses

Agieshkumar Balakrishna Pillai et al. Cell Stress Chaperones. 2022 May.

Abstract

Free radical release due to oxidative stress is gaining importance in the field of viral pathogenesis. Recent studies suggest the involvement of oxidative stress and ROS levels in regulating disease virulence during RNA virus infection. Most of the RNA virus infections lead to vascular dysfunction and disease severity. However, the biology of free radicals in maintaining vascular endothelium integrity is not completely understood. In the present review, we discuss some of the common features in positive-strand RNA virus infections such as dengue and SARS-CoV-2 and suggest that anti-oxidant therapy could pave the way to develop therapeutic strategies in combating emerging and re-emerging RNA viruses.

Keywords: Anti-oxidant therapy; COVID-19; Endothelial activation; RNA virus; ROS.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Schematic representation of ROS production and its role in virus disease pathogenesis
See this image and copyright information in PMC

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