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. 2022 Apr 2;22(1):124.
doi: 10.1186/s12890-022-01898-z.

The diagnostic value of transbronchial lung cryobiopsy combined with rapid on-site evaluation in diffuse lung diseases: a prospective and self-controlled study

Xianqiu Chen #  1 , Jie Luo #  2 , Li Yang  3 , Likun Hou  4 , Bing Jie  5 , Yang Hu  1 , Jianxiong Li  1 , Xing Jiang  1 , Jinfu Xu  1 , Kebin Cheng  6
Affiliations

The diagnostic value of transbronchial lung cryobiopsy combined with rapid on-site evaluation in diffuse lung diseases: a prospective and self-controlled study

Xianqiu Chen et al. BMC Pulm Med. .

Erratum in

Abstract

Background: The etiology of interstitial lung diseases (ILDs) is varied. Early diagnosis and a specific pathological type could significantly improve the prognosis. Mostly, it is difficult to make the etiology diagnosis of ILD through traditional biopsy methods. It will be of great significance to explore an effective biopsy method.

Methods: The prospective study was designed to evaluate the diagnostic value of transbronchial lung cryobiopsy (TBCB) combined with rapid on-site evaluation (ROSE), compared with conventional transbronchial lung biopsy (TBLB), in a large sample of ILD patients. All patients enrolled will undergo both TBLB and TBCB procedures. The study will observe the differences in the diagnostic efficiency of pathological typing and incidence of operation-related complications between TBCB and TBLB. Besides, it will analyze the relationship between the time of biopsy and the incidence of complications, the relationship between freezing time, size of specimen, and complications. And it will evaluate the consistency of pathological, clinical, and radiology.

Discussion: It may be the first time that ROSE technique will be used in the diagnosis of ILD. The results of this study will clarify the value of TBCB in the diagnosis of ILD and confirm its safety and effectiveness, which is expected to significantly improve the efficiency of diagnosis in ILD patients.

Trail registration: The trial was registered on the Chinese Clinical Trial Registry website ( http://www.chictr.org.cn/showproj.aspx?proj=57834 ) (Registration number: ChiCTR2000035492).

Keywords: Complication; Diagnosis; Interstitial lung disease (ILD); Rapid on-site evaluation (ROSE); Transbronchial lung biopsy (TBLB); Transbronchial lung cryobiopsy (TBCB).

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Research process. TBLB, transbronchial lung biopsy; TBCB, transbronchial lung cryobiopsy; ROSE, rapid on-site evaluation
Fig. 2
Fig. 2
Lung tissue obtained by transbronchial lung cryobiopsy
See this image and copyright information in PMC

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