Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct;72(5):607-620.
doi: 10.1016/j.identj.2022.02.010. Epub 2022 Mar 1.

Orofacial Mycoses in Coronavirus Disease-2019 (COVID-19): A Systematic Review

Lakshman P Samaranayake  1 , Kausar S Fakhruddin  2 , Hien C Ngo  3 , H M N M Bandara  4 , Y Y Leung  5
Affiliations

Orofacial Mycoses in Coronavirus Disease-2019 (COVID-19): A Systematic Review

Lakshman P Samaranayake et al. Int Dent J. 2022 Oct.

Abstract

Objectives: Studies reviewing orofacial mycoses in coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection are sparse. Here we review the major oral and maxillofacial mycoses of COVID-19, the associated comorbidities, and the probable precipitating factors.

Methods: English-language manuscripts published between March 2020 and October 2021 were searched using PubMed, OVID, SCOPUS, and Web of Science databases, using appropriate keywords.

Results: We identified 30 articles across 14 countries, which met the inclusion criteria of PRISMA guidelines. These yielded a total of 292 patients with laboratory-confirmed COVID-19, 51.4% (n = 150) of whom presented with oral and maxillofacial fungal infections, mainly comprising candidosis, mucormycosis, and aspergillosis. Candida infections were the most prevalent, present in 64% (n = 96), followed by mucormycosis, and only a single case of aspergillosis was noted. Oral and maxillofacial mycoses were predominantly seen in those with comorbidities, especially in those with diabetes (52.4%). Oral mucormycosis was noted in 8.6% (n = 13) and mainly manifested on the hard palate. An overall event rate of oral/maxillofacial mucormycosis manifestation in patients with COVID-19 with diabetes mellitus type 1/2 was about 94% (49/52; 95% confidence interval, 0.73%-0.89%), implying a very high association between diabetes mellitus and the latter condition. All fungal infections appeared either concurrently with COVID-19 symptoms or during the immediate recovery period.

Conclusions: SARS-CoV-2 infection-related immunosuppression, steroid therapy, as well as comorbidities such as diabetic hyperglycemia appear to be the major predisposing factors for the onset of oral and maxillofacial mycoses in patients with COVID-19 across all age groups.

Keywords: Aspergillosis; COVID-19; Candidosis; Mucormycosis; Mycoses; Orofacial; Systematic review.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest None disclosed.

Figures

Fig 1
Fig. 1
PRISMA flowchart of the literature search and study selection.
Fig 2
Fig. 2
Schematic illustration of the reviewed data on oral-fungal manifestations related to COVID-19.
Fig 3
Fig. 3
Prevalence and a 95% confidence interval of oral-maxillofacial mucormycosis manifestations in patients with/without type 1/2 diabetes comorbid conditions.
See this image and copyright information in PMC

References

    1. Lai C-C, Wang C-Y, Hsueh P-R. Co-infections among patients with COVID-19: The need for combination therapy with non-anti-SARS-CoV-2 agents? J Microbiol Immunol Infect. 2020;53(4):505–512. - PMC - PubMed
    1. Samaranayake L, Fakhruddin KS, Bandara N. Oral manifestations of coronavirus disease 2019 (COVID-19): an overview. Dent Update. 2021;48(5):418–422. doi: 10.12968/denu.2021.48.5.418. - DOI
    1. Samaranayake L. 5th ed. Elsevier; Edinburgh: 2018. Essential microbiology for dentistry.
    1. Jerônimo LS, Esteves Lima RP, Suzuki TYU, Discacciati JAC, Bhering CLB. Oral candidiasis and COVID-19 in users of removable dentures: is special oral care needed? Gerontology. 2022;68:80–85. doi: 10.1159/000515214. - DOI - PMC - PubMed
    1. Eucker J, Sezer O, Graf B, Possinger K. Mucormycoses. Mycoses. 2001;44(7-8):253–260. - PubMed

Publication types