Recording EEG in cochlear implant users: Guidelines for experimental design and data analysis for optimizing signal quality and minimizing artifacts

Abstract

Cochlear implants (CI) are neural prostheses that can restore hearing in individuals with severe to profound hearing loss. Although CIs significantly improve quality of life, clinical outcomes are still highly variable. An important part of this variability is explained by the brain reorganization following cochlear implantation. Therefore, clinicians and researchers are seeking objective measurements to investigate post-implantation brain plasticity. Electroencephalography (EEG) is a promising technique because it is objective, non-invasive, and implant-compatible, but is nonetheless susceptible to massive artifacts generated by the prosthesis's electrical activity. CI artifacts can blur and distort brain responses; thus, it is crucial to develop reliable techniques to remove them from EEG recordings. Despite numerous artifact removal techniques used in previous studies, there is a paucity of documentation and consensus on the optimal EEG procedures to reduce these artifacts. Herein, and through a comprehensive review process, we provide a guideline for designing an EEG-CI experiment minimizing the effect of the artifact. We provide some technical guidance for recording an accurate neural response from CI users and discuss the current challenges in detecting and removing CI-induced artifacts from a recorded signal. The aim of this paper is also to provide recommendations to better appraise and report EEG-CI findings.

Keywords: Artifact minimation; Cochlear implant; EEG; Evoked potential.