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. 2022 May 1;27(3):e274-e284.
doi: 10.4317/medoral.25147.

Epidemiology and survival outcomes of lip, oral cavity, and oropharyngeal squamous cell carcinoma in a southeast Brazilian population

B-V Louredo  1 , P-A Vargas, M-E Pérez-de-Oliveira, M-A Lopes, L-P Kowalski, M-P Curado
Affiliations

Epidemiology and survival outcomes of lip, oral cavity, and oropharyngeal squamous cell carcinoma in a southeast Brazilian population

B-V Louredo et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Background: Lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC) represent a major health problem in the global scenario. In South America, the highest incidence rates are seen in Brazil. Therefore, the epidemiological and clinical profile and survival outcomes of lip, oral cavity, and oropharyngeal SCC was studied in São Paulo State, Brazil.

Material and methods: The clinicopathological data of 12,099 patients with lip, oral cavity, and oropharyngeal SCC were obtained from hospital cancer registries of the Fundação Oncocentro de São Paulo, Brazil (2010-2015). Survival rates and other analyses were performed using SPSS software.

Results: A clear male predominance was observed, particularly for patients with oropharyngeal SCC (88.3%). The average age of patients was higher for lip cases (65 ± 13.5 years) compared to other sites. The schooling level was low for most patients, especially in lip cases (87.9%). Most of the patients with oral cavity (71.8%) and oropharyngeal (86.3%) SCC had advanced-stage (III-IV) disease. However, the majority of lip cases (83.3%) were at an early stage (I-II). Surgical excision was the main treatment for lip (72%) and oral cavity SCC (23.5%), and chemoradiotherapy was the main treatment for oropharyngeal SCC (40.2%). The 5-year overall survival (OS) for patients with lip, oral cavity, and oropharyngeal SCC were 66.3, 30.9, and 22.6%, respectively. Multivariate analysis revealed that the determinants of OS were different for lip, oral cavity, and oropharyngeal SCC, except for those at the clinical stage, which was an independent predictor for all sites.

Conclusions: OS-independent determinants varied according to the affected site. Oral cavity and oropharyngeal SCC presented worse survival rates than those for lip SCC.

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Conflict of interest statement

Conflicts of interest The authors state that there were no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram of selection of study sample.
Figure 2
Figure 2
Distribution of lip, oral cavity, and oropharyngeal squamous cell carcinoma diagnosed between 2010 and 2015 according to 17 Health Regional Departments of São Paulo State.
Figure 3
Figure 3
Five-year overall survival of 10,659 patients with lip, oral cavity, and oropharyngeal squamous cell carcinoma diagnosed in São Paulo State, 2010-2015, by tumour site.
See this image and copyright information in PMC

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