Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Nov;168(2):1010-3.
doi: 10.1128/jb.168.2.1010-1013.1986.

Partition functions of unit-copy plasmids can stabilize the maintenance of plasmid pBR322 at low copy number

S Austin, S Friedman, D Ludtke

Partition functions of unit-copy plasmids can stabilize the maintenance of plasmid pBR322 at low copy number

S Austin et al. J Bacteriol. 1986 Nov.

Abstract

The maintenance of plasmid pBR322 is highly unstable in a polA12 strain of Escherichia coli at 29 degrees C due to severely reduced copy number. Under these conditions, introduction of the par (partition) locus of plasmid P1 or the par (sop) region of F into pBR322 stabilizes it. A region with similar activity was detected in the P7 plasmid. The activity of the P1 par locus was dependent on the P1 parA gene product and was sensitive to par-specified incompatibility.

PubMed Disclaimer

References

    1. Biochem Biophys Res Commun. 1970 Dec 24;41(6):1538-44 - PubMed
    1. J Bacteriol. 1985 Dec;164(3):1262-70 - PubMed
    1. J Bacteriol. 1972 Mar;109(3):971-8 - PubMed
    1. Mol Gen Genet. 1975 Dec 1;141(3):263-7 - PubMed
    1. Mol Gen Genet. 1977 Mar 28;152(1):71-6 - PubMed

Publication types

LinkOut - more resources