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. 2022 Jun;8(6):445-447.
doi: 10.1016/j.trecan.2022.03.003. Epub 2022 Mar 31.

State-matched organoid models to fight pancreatic cancer

Michael Karl Melzer  1 , Elodie Roger  2 , Alexander Kleger  3
Affiliations

State-matched organoid models to fight pancreatic cancer

Michael Karl Melzer et al. Trends Cancer. 2022 Jun.

Abstract

As one of the deadliest cancers, pancreatic ductal adenocarcinoma (PDAC) requires sophisticated model systems to dissect disease onset, progression, and therapy resistance, as well as to personalize therapy. In recent years, patient- and pluripotent stem cell-derived organoids have become state-of-the-art systems to refine existing therapeutic strategies and deepen our knowledge of disease pathophysiology.

Keywords: organoids; pancreatic cancer; personalized medicine; stem cells.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

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