Identifying Electroencephalography Biomarkers in Individuals at Clinical High Risk for Psychosis in an International Multi-Site Study

Sarah Kerins^{1

2}, Judith Nottage³, Gonzalo Salazar de Pablo^{2

4

5}, Matthew J Kempton¹, Stefania Tognin^{1

6

7}, Dorien H Niemann⁸, Lieuwe de Haan⁸, Thérèse van Amelsvoort⁹, Jun Soo Kwon¹⁰, Barnaby Nelson^{11

12}, Romina Mizrahi^{13

14}, Philip McGuire^{1

15}, Paolo Fusar-Poli^{2

5

15

16}; PSYSCAN Consortium

Collaborators, Affiliations

Collaborators

PSYSCAN Consortium:
Philip McGuire, Stefania Tognin, Paolo Fusar-Poli, Matthew Kempton, Gemma Modinos, Kate Merritt, Alexis E Cullen, Andrea Mechelli, Paola Dazzan, George Gifford, Natalia Petros, Mathilde Antoniades, Andrea De Micheli, Sandra Vieira, Tom Spencer, Rene Kahn, Arija Maat, Erika van Hell, Inge Winter, Lieuwe de Haan, Frederike Schirmbeck, Benedicto Crespo-Facorro, Diana Tordesillas-Gutierrez, Esther Setien-Suero, Rosa Ayesa-Arriola, Paula Suarez-Pinilla, Victor Ortiz Garcia-de la Foz, Birte Glenthøj, Mikkel Erlang Sørensen, Bjørn H Ebdrup, Karen Tangmose, Helle Schæbel, Egill Rostrup, Oliver Gruber, Anja Richter, Bernd Krämer, Therese van Amelsvoort, Bea Campforts, Machteld Marcelis, Claudia Vingerhoets, Celso Arango, Covandonga M Díaz-Caneja, Miriam Ayora, Joost Janssen, Roberto Rodríguez-Jiménez, Marina Díaz-Marsá, Tilo Kircher, Irina Falkenberg, Florian Bitsch, Jens Sommer, Barnaby Nelson, Patrick McGorry, Paul Amminger, Meredith McHugh, Suzie Lavoie, Jessica Spark, Rebekah Street, Silvana Galderisi, Armida Mucci, Paola Bucci, Giuseppe Piegari, Daria Pietrafesa, Luigi Giuliani, Rodrigo Bressan, André Zugman, Ary Gadelha, Graccielle Rodrigues da Cunha, Jun Soo Kwon, Kang Ik Kevin Cho, Tae Young Lee, Minah Kim, Sun-Young Moon, Silvia Kyungjin Lho, Mark Weiser, Romina Mizrahi, Michael Kiang, Cory Gerritsen, Margaret Maheandiran, Sarah Ahmed, Ivana Prce, Jenny Lepock, Gabriele Sachs, Matthäus Willeit, Marzena Lenczowski, Ullrich Sauerzopf, Ana Weidenauer, Julia Furtner-Srajer, Matthias Kirschner, Anke Maatz, Achim Burrer, Philipp Stämpfli, Naemi Huber, Kawohl Wolfram

Affiliations

¹ Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
² Early Psychosis: Interventions and Clinical-Detection Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
³ Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
⁴ Institute of Psychiatry and Mental Health, CIBERSAM, Madrid, Spain.
⁵ Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón School of Medicine, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, CIBERSAM, Madrid, Spain.
⁶ Outreach and Support in South London (OASIS), South London and Maudsley NHS Foundation Trust, London, United Kingdom.
⁷ Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, Netherlands.
⁸ Department of Psychiatry, Early Psychosis Section, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
⁹ Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands.
¹⁰ Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.
¹¹ Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, VIC, Australia.
¹² Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.
¹³ Douglas Mental Health University Institute, Montreal, QC, Canada.
¹⁴ Department of Psychiatry, McGill University, Montreal, QC, Canada.
¹⁵ National Institute for Health Research, Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, King's College London, London, United Kingdom.
¹⁶ Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.

PMID: 35370849
PMCID: PMC8970279
DOI: 10.3389/fpsyt.2022.828376

Identifying Electroencephalography Biomarkers in Individuals at Clinical High Risk for Psychosis in an International Multi-Site Study

Sarah Kerins et al. Front Psychiatry. 2022.

. 2022 Mar 16:13:828376.

doi: 10.3389/fpsyt.2022.828376. eCollection 2022.

Authors

Collaborators

PSYSCAN Consortium:
Philip McGuire, Stefania Tognin, Paolo Fusar-Poli, Matthew Kempton, Gemma Modinos, Kate Merritt, Alexis E Cullen, Andrea Mechelli, Paola Dazzan, George Gifford, Natalia Petros, Mathilde Antoniades, Andrea De Micheli, Sandra Vieira, Tom Spencer, Rene Kahn, Arija Maat, Erika van Hell, Inge Winter, Lieuwe de Haan, Frederike Schirmbeck, Benedicto Crespo-Facorro, Diana Tordesillas-Gutierrez, Esther Setien-Suero, Rosa Ayesa-Arriola, Paula Suarez-Pinilla, Victor Ortiz Garcia-de la Foz, Birte Glenthøj, Mikkel Erlang Sørensen, Bjørn H Ebdrup, Karen Tangmose, Helle Schæbel, Egill Rostrup, Oliver Gruber, Anja Richter, Bernd Krämer, Therese van Amelsvoort, Bea Campforts, Machteld Marcelis, Claudia Vingerhoets, Celso Arango, Covandonga M Díaz-Caneja, Miriam Ayora, Joost Janssen, Roberto Rodríguez-Jiménez, Marina Díaz-Marsá, Tilo Kircher, Irina Falkenberg, Florian Bitsch, Jens Sommer, Barnaby Nelson, Patrick McGorry, Paul Amminger, Meredith McHugh, Suzie Lavoie, Jessica Spark, Rebekah Street, Silvana Galderisi, Armida Mucci, Paola Bucci, Giuseppe Piegari, Daria Pietrafesa, Luigi Giuliani, Rodrigo Bressan, André Zugman, Ary Gadelha, Graccielle Rodrigues da Cunha, Jun Soo Kwon, Kang Ik Kevin Cho, Tae Young Lee, Minah Kim, Sun-Young Moon, Silvia Kyungjin Lho, Mark Weiser, Romina Mizrahi, Michael Kiang, Cory Gerritsen, Margaret Maheandiran, Sarah Ahmed, Ivana Prce, Jenny Lepock, Gabriele Sachs, Matthäus Willeit, Marzena Lenczowski, Ullrich Sauerzopf, Ana Weidenauer, Julia Furtner-Srajer, Matthias Kirschner, Anke Maatz, Achim Burrer, Philipp Stämpfli, Naemi Huber, Kawohl Wolfram

Affiliations

¹ Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
² Early Psychosis: Interventions and Clinical-Detection Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
³ Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
⁴ Institute of Psychiatry and Mental Health, CIBERSAM, Madrid, Spain.
⁵ Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón School of Medicine, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, CIBERSAM, Madrid, Spain.
⁶ Outreach and Support in South London (OASIS), South London and Maudsley NHS Foundation Trust, London, United Kingdom.
⁷ Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, Netherlands.
⁸ Department of Psychiatry, Early Psychosis Section, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
⁹ Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands.
¹⁰ Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.
¹¹ Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, VIC, Australia.
¹² Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.
¹³ Douglas Mental Health University Institute, Montreal, QC, Canada.
¹⁴ Department of Psychiatry, McGill University, Montreal, QC, Canada.
¹⁵ National Institute for Health Research, Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, King's College London, London, United Kingdom.
¹⁶ Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.

PMID: 35370849
PMCID: PMC8970279
DOI: 10.3389/fpsyt.2022.828376

Abstract

Background: The clinical high-risk for psychosis (CHR-P) paradigm was introduced to detect individuals at risk of developing psychosis and to establish preventive strategies. While current prediction of outcomes in the CHR-P state is based mostly on the clinical assessment of presenting features, several emerging biomarkers have been investigated in an attempt to stratify CHR-P individuals according to their individual trajectories and refine the diagnostic process. However, heterogeneity across subgroups is a key challenge that has limited the impact of the CHR-P prediction strategies, as the clinical validity of the current research is limited by a lack of external validation across sites and modalities. Despite these challenges, electroencephalography (EEG) biomarkers have been studied in this field and evidence suggests that EEG used in combination with clinical assessments may be a key measure for improving diagnostic and prognostic accuracy in the CHR-P state. The PSYSCAN EEG study is an international, multi-site, multimodal longitudinal project that aims to advance knowledge in this field.

Methods: Participants at 6 international sites take part in an EEG protocol including EEG recording, cognitive and clinical assessments. CHR-P participants will be followed up after 2 years and subcategorised depending on their illness progression regarding transition to psychosis. Differences will be sought between CHR-P individuals and healthy controls and between CHR-P individuals who transition and those who do not transition to psychosis using data driven computational analyses.

Discussion: This protocol addresses the challenges faced by previous studies of this kind to enable valid identification of predictive EEG biomarkers which will be combined with other biomarkers across sites to develop a prognostic tool in CHR-P. The PSYSCAN EEG study aims to pave the way for incorporating EEG biomarkers in the assessment of CHR-P individuals, to refine the diagnostic process and help to stratify CHR-P subjects according to risk of transition. This may improve our understanding of the CHR-P state and therefore aid the development of more personalized treatment strategies.

Keywords: CHR-P; EEG; biomarkers; multi-site; psychosis prediction.

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Conflict of interest statement

TA was employed by GGZE Mental Health Care. BN was employed by Orygen, The National Centre of Excellence in Youth Mental Health. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

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Identifying Electroencephalography Biomarkers in Individuals at Clinical High Risk for Psychosis in an International Multi-Site Study

Collaborators

Affiliations

Identifying Electroencephalography Biomarkers in Individuals at Clinical High Risk for Psychosis in an International Multi-Site Study

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

References

LinkOut - more resources

Full Text Sources