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. 2022 Mar 23:2022:1503167.
doi: 10.1155/2022/1503167. eCollection 2022.

Validation of the Japanese Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS)

Maiko Takahashi  1 , Jinsoo Koh  1 , Shoko Yorozu  2 , Yoshinori Kajimoto  1 , Yoshiaki Nakayama  1 , Mayumi Sakata  1 , Masaaki Yasui  1 , Yasuhiro Hiwatani  2 , Daniel Weintraub  3 , Hidefumi Ito  1
Affiliations

Validation of the Japanese Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS)

Maiko Takahashi et al. Parkinsons Dis. .

Abstract

Introduction: The Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (PD)-Rating Scale (QUIP-RS) was developed to assess the severity of impulsive and compulsive behaviors (ICBs) in PD. We aimed to validate the Japanese version of QUIP-RS and determine the characteristics of ICBs in Japan.

Methods: We translated the QUIP-RS into Japanese, back-translated it to English, and obtained confirmation from the original author that the questionnaire remained appropriate. The participants for the validation study were 161 PD patients, identified by continuous sampling at two institutions, who were diagnosed with ICBs through a semistructured interview and completed the QUIP-RS-J. Sensitivity, specificity, and cutoff values were calculated using receiver operating characteristic (ROC) curves. Interinstitutional reliability and test-retest reliability were also assessed for a subset of participants.

Results: Twenty-six (16.1%) participants were diagnosed with ICB. The optimal cutoff value of the QUIP-RS-J total score was 6, with area under the curve (AUC) = 0.889 and sensitivity/specificity of 0.92/0.71. Each subscale also showed high AUC (0.89-1.00), sensitivity (0.92-1.00), and specificity (0.71-1.00). Compared with the English version, the optimal cutoff point for binge eating was higher and hypersexuality lower. The total score tended to be higher when described by an informant.

Conclusion: The present study validated the Japanese version of QUIP-RS. Use of QUIP-RS-J enables standardized assessment of ICBs and can be used in clinical research, including international multicenter studies.

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Conflict of interest statement

Daniel Weintraub received license fee payments from the University of Pennsylvania for QUIP and QUIP-RS. The other authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Relative frequencies of the impulsive-compulsive disorders (ICDs) by a semistructured interview. DDS, dopamine dysregulation syndrome; ICBs, impulsive-compulsive behaviors; ICDs, impulse control disorders.
Figure 2
Figure 2
Receiver-operator characteristics (ROC) curve from the diagnosis of ICBs versus QUIP-RS score. The optimal cutoff value was 6, with a sensitivity of 0.92 and a specificity of 0.71. Area under the curve (AUC) was 0.889.
See this image and copyright information in PMC

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