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. 2022 Mar 17:12:846568.
doi: 10.3389/fonc.2022.846568. eCollection 2022.

The Value of Shear Wave Elastography in the Diagnosis of Breast Cancer Axillary Lymph Node Metastasis and Its Correlation With Molecular Classification of Breast Masses

Changyun Luo  1 , Li Lu  2 , Weifu Zhang  3 , Xiangqi Li  4 , Ping Zhou  5 , Zhangshen Ran  1
Affiliations

The Value of Shear Wave Elastography in the Diagnosis of Breast Cancer Axillary Lymph Node Metastasis and Its Correlation With Molecular Classification of Breast Masses

Changyun Luo et al. Front Oncol. .

Abstract

Objective: To explore the diagnostic value of shear wave elastography examination (SWE) on axillary node metastasis (ANM) in breast cancer, this study aimed to evaluate the correlation between the SWE features and different molecular types of breast cancer, and to check the elastic modulus differences among the molecular types.

Methods: Breast cancer patients from November 2020 to December 2021 were subjected to both conventional ultrasonic examination (CUE) and SWE before ultrasound-guided percutaneous biopsy or axillary lymph node dissection (ALND). We used the pathological results as the gold standard to draw the receiver operating characteristic (ROC) curve.

Results: SWE outperforms CUE, but their conjunctive use is the best option. No significant correlation was found between the elastic modulus values and the molecular types of breast cancer.

Conclusion: SWE can be used as an routine auxiliary method of CUE for ANM.

Keywords: breast cancer; diagnosis; metastasis; molecular classification; shear wave elastography.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Three ROC curves for the sensitivity and specificity of CUE, SWE, and their conjunctive use in ANM diagnosis.
Figure 2
Figure 2
Three ROC curves for the sensitivity and specificity of the Emean, Emax, and Emin in the application of ANM diagnosis.
See this image and copyright information in PMC

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