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Review
. 2022 Mar 14:10:823785.
doi: 10.3389/fchem.2022.823785. eCollection 2022.

Structure-Property Relationship for Different Mesoporous Silica Nanoparticles and its Drug Delivery Applications: A Review

Parya Kazemzadeh  1 , Khalil Sayadi  2 , Ali Toolabi  3 , Jalil Sayadi  4 , Malihe Zeraati  5 , Narendra Pal Singh Chauhan  6 , Ghasem Sargazi  7
Affiliations
Review

Structure-Property Relationship for Different Mesoporous Silica Nanoparticles and its Drug Delivery Applications: A Review

Parya Kazemzadeh et al. Front Chem. .

Abstract

Mesoporous silica nanoparticles (MSNs) are widely used as a promising candidate for drug delivery applications due to silica's favorable biocompatibility, thermal stability, and chemical properties. Silica's unique mesoporous structure allows for effective drug loading and controlled release at the target site. In this review, we have discussed various methods of MSNs' mechanism, properties, and its drug delivery applications. As a result, we came to the conclusion that more in vivo biocompatibility studies, toxicity studies, bio-distribution studies and clinical research are essential for MSN advancement.

Keywords: drug delivery; mesoporous; nanoparticles; properties; silica.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Preparation route for CAIX guided mesoporous silica nanoparticles (Chen et al., 2020).
FIGURE 2
FIGURE 2
Possible pathways for the synthesis of mesoporous materials (A) Liquid crystal templating and (B) self-assembly.
FIGURE 3
FIGURE 3
Synthesis of MCM-41 in basic media (Janicke et al., 1999).
FIGURE 4
FIGURE 4
Loading of folic acid into SBA-15/NH2.
FIGURE 5
FIGURE 5
Functionalization of mesoporous silica by grafting.
See this image and copyright information in PMC

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