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. 2022 Mar 18:9:863273.
doi: 10.3389/fsurg.2022.863273. eCollection 2022.

Complete Video-Assisted Thoracoscopic Surgery and Traditional Open Surgery for Elderly Patients With NSCLC

Yi Mao  1 , Zhaojia Gao  1 , Yajun Yin  1
Affiliations

Complete Video-Assisted Thoracoscopic Surgery and Traditional Open Surgery for Elderly Patients With NSCLC

Yi Mao et al. Front Surg. .

Abstract

Objective: To observe the efficacy of complete video-assisted thoracoscopic surgery (CVATS) and traditional open surgery (TOS) in the treatment of elderly patients with non-small cell lung cancer (NSCLC) and their influence on cardiopulmonary function.

Methods: A total of 120 elderly patients with primary NSCLC who were treated surgically in our hospital from January 2018 to January 2021 were selected and divided into the study group and the control group according to the different surgical procedures, 60 patients in each group. CVATS was used in the observation group and TOS in the control group. The surgical indexes and cardiopulmonary function indexes were observed and compared between the two groups. The serum C-reactive protein (CRP) level and visual analog scale's (VAS) score of the patients at different time points were detected. The incidence of postoperative complications was compared between the two groups.

Results: The perioperative indexes such as operation time were significantly different between the two groups (p < 0.05), but the number of lymph node dissection was not significantly different (p > 0.05). The serum CRP level and VAS score of the observation group were significantly lower than those of the control group on the 1st, 3rd, and 7th postoperative days (p < 0.05). There were significant differences in cardiopulmonary function between the two groups on the 7th postoperative day (p < 0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (p > 0.05).

Conclusion: CVATS is effective in the treatment of NSCLC. Compared with TOS therapy, CVATS has less damage to cardiopulmonary function and fewer complications, which is conducive to the rehabilitation of elderly patients. It is a safe and reliable scheme for the treatment of elderly patients with NSCLC.

Keywords: cardiopulmonary function; complete video-assisted thoracoscopic surgery; lymph node dissection; non-small cell lung cancer; traditional open surgery.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Comparison of CRP levels in the patients of the two groups. Compared with preoperative, *p < 0.05. Compared with the control group, #p < 0.05.
Figure 2
Figure 2
Comparison of VAS scores in the patients of the two groups. Compared with postoperative, *p < 0.05. Compared with the control group, #p < 0.05.
Figure 3
Figure 3
Comparison of HR changes in the patients of the two groups. Compared with preoperative, *p < 0.05. Compared with the control group, #p < 0.05.
Figure 4
Figure 4
Comparison of FEV1 changes in the patients of the two groups. Compared with preoperative, *p < 0.05. Compared with the control group, #p < 0.05.
Figure 5
Figure 5
Comparison of MVV changes in the patients of the two groups. Compared with preoperative, *p < 0.05. Compared with the control group, #p < 0.05.
Figure 6
Figure 6
Comparison of DLCD changes in the patients of the two groups. Compared with preoperative, *p < 0.05. Compared with the control group, #p < 0.05.
Figure 7
Figure 7
Comparison of the incidence of adverse reactions between the two groups. Compared with the control group, *p < 0.05.
See this image and copyright information in PMC

References

    1. Duma N, Santana-Davila R, Molina JR. Non-small cell lung cancer: epidemiology, screening, diagnosis, and treatment. Mayo Clin Proc. (2019) 94:1623–40. 10.1016/j.mayocp.2019.01.013 - DOI - PubMed
    1. Alexander M, Kim SY, Cheng H. Update 2020: management of non-small cell lung cancer. Lung. (2020) 198:897–907. 10.1007/s00408-020-00407-5 - DOI - PMC - PubMed
    1. Yang HX, Woo KM, Sima CS, Bains MS, Adusumilli PS, Huang J, et al. Long-term survival based on the surgical approach to lobectomy for clinical stage I nonsmall cell lung cancer: comparison of robotic, video-assisted thoracic surgery, and thoracotomy lobectomy. Ann Surg. (2017) 265:431–7. 10.1097/SLA.0000000000001708 - DOI - PMC - PubMed
    1. Mun M, Nakao M, Matsuura Y, Ichinose J, Nakagawa K, Okumura S. Video-assisted thoracoscopic surgery lobectomy for non-small cell lung cancer. Gen Thorac Cardiovasc Surg. (2018) 66:626–31. 10.1007/s11748-018-0979-x - DOI - PubMed
    1. Tsou KC, Hsu HH, Tsai TM, Chen KC, Chen JS. Clinical outcome of subcentimeter non-small cell lung cancer after VATS resection: Single institute experience with 424 patients. J Formos Med Assoc. (2020) 119:399–405. 10.1016/j.jfma.2019.07.004 - DOI - PubMed