The phagocytosis of yeast cells by monocytes: effects of colchicine, beta-lumicolchicine, and gamma-lumicolchicine
- PMID: 3537551
The phagocytosis of yeast cells by monocytes: effects of colchicine, beta-lumicolchicine, and gamma-lumicolchicine
Abstract
The effect of microtubule antagonist (MA) colchicine and its two non-MA derivatives beta-lumicolchicine and gamma-lumicolchicine on the phagocytosis of yeast cells by glass-adherent monocytes were studied with a fluorescence quenching technique which allowed a distinction between the adherence and engulfment phases of phagocytosis. The engulfment of yeast cells was depressed by colchicine (p = 0.031) but not by the lumicolchicines. The adherence of yeast cells to the monocytes, on the other hand, was depressed by gamma-lumicolchicine (p = 0.028). The colchicine effect suggests that cytoplasmic microtubules play a role in the engulfment process whereas the lumicolchicine effect suggests a role of nucleoside transport over the cell membrane in the adherence process of phagocytosis.
Similar articles
-
Comparison of the effects of colchicine and beta-lumicolchicine on cultured adrenal chromaffin cells: lack of evidence for an action of colchicine on receptor-associated microtubules.Pharmacology. 1987;35(3):155-62. doi: 10.1159/000138307. Pharmacology. 1987. PMID: 3685083
-
Factors involved in the sensitivity of Stentor to colchicine, lumicolchicine, and vinblastine sulfate.Eur J Cell Biol. 1983 Sep;31(2):205-11. Eur J Cell Biol. 1983. PMID: 6641735
-
Microtubule inhibitors differentially affect translational movement, cell surface expression, and endocytosis of transferrin receptors in K562 cells.J Cell Physiol. 1994 Aug;160(2):345-57. doi: 10.1002/jcp.1041600216. J Cell Physiol. 1994. PMID: 7913709
-
[Effect of drugs on human neutrophilic granulocyte functions].Rev Med Interna Neurol Psihiatr Neurochir Dermatovenerol Med Interna. 1978 Sep-Oct;30(5):393-400. Rev Med Interna Neurol Psihiatr Neurochir Dermatovenerol Med Interna. 1978. PMID: 32592 Review. Romanian. No abstract available.
-
[Microtubule inhibitors--its application to the research field of hard tissues (author's transl)].Kokubyo Gakkai Zasshi. 1981 Jun;48(2):199-218. Kokubyo Gakkai Zasshi. 1981. PMID: 7026704 Review. Japanese. No abstract available.
Cited by
-
A cytostatic drug (taxol) which does not inhibit monocyte phagocytosis.Med Oncol Tumor Pharmacother. 1988;5(2):135-8. doi: 10.1007/BF02985453. Med Oncol Tumor Pharmacother. 1988. PMID: 2900916
-
MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages.Mol Biol Cell. 2007 Jul;18(7):2389-99. doi: 10.1091/mbc.e06-12-1128. Epub 2007 Apr 18. Mol Biol Cell. 2007. PMID: 17442887 Free PMC article.
-
Microtubule-dependent cell polarity regulates skin-resident macrophage phagocytosis and directed cell migration.bioRxiv [Preprint]. 2025 Mar 14:2025.03.13.642867. doi: 10.1101/2025.03.13.642867. bioRxiv. 2025. PMID: 40161838 Free PMC article. Preprint.