Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec;35(6):1136-1150.
doi: 10.1111/jhn.13012. Epub 2022 Apr 17.

A higher energy-adjusted Dietary Inflammatory Index is positively associated with total and visceral body fat in young male adults

Cinthia R Corrêa  1   2 , Bruno G G da Costa  3 , Kelly S Silva  3 , Nitin Shivappa  4   5 , Michael D Wirth  4   5   6 , James R Hébert  4   5 , Everson A Nunes  1   2
Affiliations

A higher energy-adjusted Dietary Inflammatory Index is positively associated with total and visceral body fat in young male adults

Cinthia R Corrêa et al. J Hum Nutr Diet. 2022 Dec.

Abstract

Background: The energy-adjusted Dietary Inflammatory Index (E-DII™) has been associated with a high body mass index and markers of chronic diseases. Also, pro-inflammatory diets with a high E-DII have been positively associated with metabolic disturbances such as glucose intolerance and type II diabetes mellitus. However, it is unclear whether E-DII scores are positively associated with body fat percentage and visceral fat per se. This cross-sectional study aimed to evaluate whether the E-DII is associated with body fat content and metabolic health indicators in lean and obese young men.

Methods: The present study was conducted on 59 participants, without comorbidities, not using tobacco, medication and nutritional supplements. Dietary data were obtained by 3-day food records to calculate E-DII scores based on 28 food parameters. Body composition was assessed by dual X-ray absorptiometry (DXA). Blood samples were taken to measure fasting glucose, insulin, triacylglycerols, total cholesterol, and low- and high-density lipoprotein cholesterol. An oral glucose tolerance test also was performed. Associations were determined by mixed-effects linear regression.

Results: E-DII scores ranged from -3.48 to +3.10. Energy intake was similar across E-DII tertiles. After adjusting for covariates, the highest E-DII tertile was associated with increased body fat, visceral adipose tissue and waist circumference. There was no association between E-DII scores and glycaemic parameters.

Conclusions: In young participants, a dietary pattern with a higher E-DII (i.e., pro-inflammatory) score was associated with high body fat and markers of central adiposity assessed by DXA, regardless of body mass.

Keywords: attitudes and behaviour; chronic disease; dietary influences; disease/therapeutic areas; obesity.

PubMed Disclaimer

References

REFERENCES

    1. Libby P. Inflammatory mechanisms: the molecular basis of inflammation and disease. Nutr Rev. 2007;65(12):s140-6. https://doi.org/10.1301/nr.2007.dec.S140
    1. Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25(12):1822-32. https://doi.org/10.1038/s41591-019-0675-0
    1. Calder PC, Ahluwalia N, Brouns F, Buetler T, Clement K, Cunningham K, et al. Dietary factors and low-grade inflammation in relation to overweight and obesity. Br J Nutr. 2011;106(S3):S5-78. https://doi.org/10.1017/S0007114511005460
    1. Kotas ME, Medzhitov R. Homeostasis, inflammation, and disease susceptibility. Cell. 2015;160(5):816-27. https://doi.org/10.1016/j.cell.2015.02.010
    1. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444(7121):860-7. https://doi.org/10.1038/nature05485

Publication types

LinkOut - more resources