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Comment
. 2022 Aug;44(4):e179-e180.
doi: 10.1111/ijlh.13841. Epub 2022 Apr 4.

Definite diagnosis of plasma prekallikrein deficiency should not be based exclusively on shortening of the aPTT upon prolonged pre-incubation

Anke Adenaeuer  1   2 , Stefano Barco  1   3 , Alice Trinchero  4 , Karl J Lackner  1   2 , Bernhard Lämmle  1   5   6 , Heidi Rossmann  1   2
Affiliations
Comment

Definite diagnosis of plasma prekallikrein deficiency should not be based exclusively on shortening of the aPTT upon prolonged pre-incubation

Anke Adenaeuer et al. Int J Lab Hematol. 2022 Aug.
No abstract available

Keywords: activated partial thromboplastin time; blood coagulation; genetics; high molecular weight kininogen deficiency; prekallikrein deficiency.

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Comment in

  • Prekallikrein deficiency: Challenges in laboratory testing.
    Abraham R, Viswanathan GK, Dass J, Dhawan R, Aggarwal M, Kumar P, Seth T, Mahapatra M. Abraham R, et al. Int J Lab Hematol. 2022 Aug;44(4):e185-e186. doi: 10.1111/ijlh.13843. Epub 2022 Apr 4. Int J Lab Hematol. 2022. PMID: 35377535 No abstract available.

Comment on

References

REFERENCES

    1. Abraham RM, Viswanathan GK, Dass J, et al. Prekallikrein deficiency due to homozygous KLKB1(+) mutation c.444_445insT (p.Ser151PhefsTer34). Int J Lab Hematol. 2021;1-3. doi:10.1111/ijlh.13773
    1. Barco S, Sollfrank S, Trinchero A, et al. Severe plasma prekallikrein deficiency: clinical characteristics, novel KLKB1 mutations, and estimated prevalence. J Thromb Haemost. 2020;18(7):1598-1617. doi:10.1111/jth.14805
    1. Adenaeuer A, Ezigbo ED, Fawzy Nazir H, et al. c.451dupT in KLKB1 is common in Nigerians, confirming a higher prevalence of severe prekallikrein deficiency in Africans compared to Europeans. J Thromb Haemost. 2021;19(1):147-152. doi:10.1111/jth.15137
    1. Asmis LM, Sulzer I, Furlan M, Lämmle B. Prekallikrein deficiency: the characteristic normalization of the severely prolonged aPTT following increased preincubation time is due to autoactivation of factor XII. Thromb Res. 2002;105(6):463-470. doi:10.1016/s0049-3848(02)00045-2
    1. Maak B, Kochhan L, Heuchel P, Jenderny J. Schwerer Präkallikreinmangel infolge einer compound-heterozygotie im KLKB1-gen. Hamostaseologie. 2009;29(2):187-189.

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