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Review
. 2022;18(5):24-33.
doi: 10.2174/1573403X18666220404152924.

Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging

Yenni Limyati  1   2   3 , Ardo Sanjaya  1   4 , Teresa Lucretia  5 , Julia Windi Gunadi  6 , Vitriana Biben  7 , Diana Krisanti Jasaputra  8 , Ronny Lesmana  9   10
Affiliations
Review

Potential Role of Exercise in Regulating YAP and TAZ During Cardiomyocytes Aging

Yenni Limyati et al. Curr Cardiol Rev. 2022.

Abstract

Adaptation of cardiac muscle to regular exercise results in morphological and structural changes known as physiological cardiac hypertrophy, to which the Hippo signaling pathway might have contributed. Two major terminal effectors in the Hippo signaling pathway are Yes-associated protein (YAP) and its homolog transcriptional coactivator with PDZ-binding motif (TAZ). The latest studies have reported the role of YAP and TAZ in different life stages, such as in fetal, neonatal, and adult hearts. Their regulation might involve several mechanisms and effectors. One of the possible coregulators is exercise. Exercise plays a role in cardiomyocyte hypertrophic changes during different stages of life, including in aged hearts. YAP/TAZ signaling pathway has a role in physiological cardiac hypertrophy induced by exercise and is associated with cardiac remodelling. Thus, it can be believed that exercise has roles in activating the signaling pathway of YAP and TAZ in aged cardiomyocytes. However, the studies regarding the roles of YAP and TAZ during cardiomyocyte aging are limited. The primary purpose of this review is to explore the response of cardiovascular aging to exercise via signaling pathway of YAP and TAZ.

Keywords: Aging; TAZ; YAP; cardiac hypertrophy; cardiomyocyte; exercise.

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Figures

Fig. (1)
Fig. (1)
A Simple schematic for the hippo pathways signaling cascade.
Fig. (2)
Fig. (2)
Schematic showing the regulation of exercise on YAP and TAZ in cardiomyocytes adaptation and aging. Black lines are stimulation, and red lines are inhibition.
See this image and copyright information in PMC

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