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. 2022 Aug;33(8):1815-1821.
doi: 10.1007/s00198-022-06390-2. Epub 2022 Apr 5.

Associations of components of sarcopenia with risk of fracture in the Osteoporotic Fractures in Men (MrOS) study

R J Harris  1   2 , N Parimi  3 , P M Cawthon  3 , E S Strotmeyer  4 , R M Boudreau  4 , J S Brach  5 , C K Kwoh  6 , J A Cauley  4
Affiliations

Associations of components of sarcopenia with risk of fracture in the Osteoporotic Fractures in Men (MrOS) study

R J Harris et al. Osteoporos Int. 2022 Aug.

Abstract

Our aim was to evaluate the associations between the individual components of sarcopenia and fracture types. In this cohort, the risk of experiencing any clinical, hip, or major osteoporotic fracture is greater in men with slow walking speed in comparison to normal walking speed.

Introduction: The association between the components of sarcopenia and fractures has not been clearly elucidated and has hindered the development of appropriate therapeutic interventions. Our aim was to evaluate the associations between the individual components of sarcopenia, specifically lean mass, strength, and physical performance and fracture (any fracture, hip fracture, major osteoporotic fracture) in the Osteoporotic Fractures in Men (MrOS) study.

Methods: The Osteoporotic Fractures in Men study (MrOS) recruited 5995 men ≥ 65 years of age. We measured appendicular lean mass (ALM) by dual-energy X-ray absorptiometry (low as residual value < 20th percentile for the cohort), walking speed (fastest trial of usual pace, values < 0.8 m/s were low), and grip strength (max score of 2 trials, values < 30 kg were low). Information on fractures was assessed tri-annually over an average follow-up of 12 years and centrally adjudicated. Cox proportional hazard models estimated the hazard ratio (HR) (95% confidence intervals) for slow walking speed, low grip strength, and low lean mass.

Results: Overall, 1413 men had a fracture during follow-up. Slow walking speed was associated with an increased risk for any HR = 1.39, 1.05-1.84; hip HR = 2.37, 1.54-3.63; and major osteoporotic, HR = 1.89, 1.34-2.67 in multi-variate-adjusted models. Low lean mass and low grip strength were not significantly associated with fracture.

Conclusions: In this cohort of older adult men, the risk of experiencing any, hip, or major osteoporotic fracture is greater in men with slow walking speed in comparison to men with normal walking speed, but low grip strength and low lean mass were not associated with fracture.

Keywords: Aging; Fractures; Gait speed; Sarcopenia.

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Conflict of interest statement

Conflict of Interest: Rebekah Harris, Neeta Parimi, Peggy M. Cawthon, Elsa S. Strotmeyer, Robert M. Boudreau, Jennifer S. Brach, C. Kent Kwoh, Jane A. Cauley report no conflict of interest.

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References

    1. Bhasin S, T.T., Manini TM, Patel S, et al., Sarcopenia Definition: The Position Statements of the Sarcopenia Definition and Outcomes Consortium. Journal of the American Geriatrics Society, 2020. 00: p. 1–9. - PubMed
    1. Epidemiologic and methodologic problems in determining nutritional status of older persons. 1988. Albuquerque, New Mexico: American Journal of Clinical Nutrition. - PubMed
    1. Orwoll ES, et al., The Importance of Muscle Versus Fat Mass in Sarcopenic Obesity: A Re-evaluation Using D3-Creatine Muscle Mass Versus DXA Lean Mass Measurements. The Journals of Gerontology: Series A, 2020. 75(7): p. 1362–1368. - PMC - PubMed
    1. Delmonico MJ, et al., Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. J Am Geriatr Soc, 2007. 55(5): p. 769–74. - PubMed
    1. McLean RR, et al., Lower Lean Mass Measured by Dual-Energy X-ray Absorptiometry (DXA) is Not Associated with Increased Risk of Hip Fracture in Women: The Framingham Osteoporosis Study. Calcified Tissue International, 2018. 103(1): p. 16–23. - PMC - PubMed