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. 2022 Apr 21;58(33):5136-5139.
doi: 10.1039/d2cc00121g.

Glycomimetic ligands block the interaction of SARS-CoV-2 spike protein with C-type lectin co-receptors

Sara Pollastri  1 , Clara Delaunay  2 , Michel Thépaut  2 , Franck Fieschi  2 , Anna Bernardi  1
Affiliations
Free article

Glycomimetic ligands block the interaction of SARS-CoV-2 spike protein with C-type lectin co-receptors

Sara Pollastri et al. Chem Commun (Camb). .
Free article

Abstract

The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells. We tested C2 triazole-modified mono- and pseudo-di-mannosides as inhibitors of DC/L-SIGN binding to a model mannosylated protein (Man-BSA) and to SARS-CoV2 spike, finding that they inhibit the interaction of both lectins with the spike glycoprotein in a Surface Plasmon Resonance (SPR) assay and are more potent than mannose by up to 36-fold (DC-SIGN) and 10-fold (L-SIGN). The molecules described here are the first known glycomimetic ligands of L-SIGN.

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