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. 2022 Apr 5;15(728):eabq3005.

doi: 10.1126/scisignal.abq3005. Epub 2022 Apr 5.

Brain aging by gut AGE

Leslie K Ferrarelli¹

Affiliations

PMID: 35380878
DOI: 10.1126/scisignal.abq3005

Comment

Brain aging by gut AGE

Leslie K Ferrarelli. Sci Signal. 2022.

. 2022 Apr 5;15(728):eabq3005.

doi: 10.1126/scisignal.abq3005. Epub 2022 Apr 5.

Author

Leslie K Ferrarelli¹

Affiliation

¹ Science Signaling, AAAS, Washington, DC 20005, USA. Email: lferrare@aaas.org.

PMID: 35380878
DOI: 10.1126/scisignal.abq3005

Abstract

An advanced glycation end product (AGE) links the gut microbiome, a "leaky gut," and microglial aging.

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Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N⁶-carboxymethyllysine.
Mossad O, Batut B, Yilmaz B, Dokalis N, Mezö C, Nent E, Nabavi LS, Mayer M, Maron FJM, Buescher JM, de Agüero MG, Szalay A, Lämmermann T, Macpherson AJ, Ganal-Vonarburg SC, Backofen R, Erny D, Prinz M, Blank T. Mossad O, et al. Nat Neurosci. 2022 Mar;25(3):295-305. doi: 10.1038/s41593-022-01027-3. Epub 2022 Mar 3. Nat Neurosci. 2022. PMID: 35241804

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