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. 2022 Apr 5;17(4):e0266452.
doi: 10.1371/journal.pone.0266452. eCollection 2022.

Evaluation of community-based screening tools for the early screening of osteoporosis in postmenopausal Vietnamese women

My Hanh Bui  1   2 , Phuoc Thang Dao  3 , Quynh Long Khuong  4 , Phuong-Anh Le  2 , Thuy-Trang Thi Nguyen  2 , Gia Du Hoang  5 , Tu Hoang Le  6 , Hoai Thu Pham  1   2 , Hong-Xuyen Thi Hoang  2 , Quang Cuong Le  1 , Xuan Thanh Dao  1   2
Affiliations

Evaluation of community-based screening tools for the early screening of osteoporosis in postmenopausal Vietnamese women

My Hanh Bui et al. PLoS One. .

Abstract

Background: Osteoporosis affects people worldwide. However, there are few validated tools for the early screening of osteoporosis in Vietnam. We set out to evaluate the performance of the osteoporosis self-assessment tool for Asians (OSTA) and the osteoporosis screening tool for Chinese (OSTC) for the early screening of osteoporosis in postmenopausal Vietnamese women.

Methods: We analyzed retrospective data from 797 postmenopausal Vietnamese women. The bone mineral density (BMD) in the lumbar vertebrae (L1-L4) and the left and right femoral necks of all participants were measured using dual-energy X-ray absorptiometry (DXA). Osteoporosis was defined as the BMD (T-score) < -2.5. The OSTA and OSTC scores were calculated from the age and weight of participants. Receiver operating characteristic analysis was conducted to compare the performance of the two tools with the BMD measurements by DXA at different anatomical sites.

Results: The rates of osteoporosis determined by BMD varied between anatomical sites, and ranged from 43.4% to 54.7% in the lumbar vertebrae and 29.2% and 8.9% in the left and right femoral necks, respectively. For the vertebrae, the area under the curve (AUC) for OSTA ranged from 70.9% to 73.9% and for OSTC ranged from 68.7% to 71.6%. The predictive value of both tools was higher for femoral necks, with the AUC of OSTA for the left and right femoral necks being 80.0% and 85.8%, respectively. The corresponding figures for OSTC were 80.5% and 86.4%, respectively. The highest sensitivity and specificity of OSTA were 74.6% and 81.4%, while these figures for OSTC were 73.9% and 82.6%, respectively.

Conclusion: OSTA and OSTC were shown to be useful self-assessment tools for osteoporosis detection in Vietnam postmenopausal women. Further research is encouraged to determine the applicability of tools for other populations and settings.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. BMD classification and risk of osteoporosis determined by OSTA and OSTC.
Fig 2
Fig 2. ROC analysis of the predictive value of the OSTA and OSTC as compared to the BMD measurement in different anatomical sites.
See this image and copyright information in PMC

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