Hyperlipidemia, COVID-19 and acute pancreatitis: A tale of three entities

doi:10.1016/j.amjms.2022.03.007

Review

. 2022 Sep;364(3):257-263.

doi: 10.1016/j.amjms.2022.03.007. Epub 2022 Apr 4.

Hyperlipidemia, COVID-19 and acute pancreatitis: A tale of three entities

Qiuyi Tang¹, Lin Gao², Zhihui Tong³, Weiqin Li⁴

Affiliations

¹ Medical School, Southeast University, Nanjing, Jiangsu, China; Center of Severe Acute Pancreatitis (CSAP), Department of Intensive Care Unit, Jinling Hospital, Nanjing, Jiangsu, China.
² Center of Severe Acute Pancreatitis (CSAP), Department of Intensive Care Unit, Jinling Hospital, Nanjing, Jiangsu, China.
³ Center of Severe Acute Pancreatitis (CSAP), Department of Intensive Care Unit, Jinling Hospital, Nanjing, Jiangsu, China. Electronic address: njzyantol@hotmail.com.
⁴ Medical School, Southeast University, Nanjing, Jiangsu, China; Center of Severe Acute Pancreatitis (CSAP), Department of Intensive Care Unit, Jinling Hospital, Nanjing, Jiangsu, China. Electronic address: njzy_pancrea@163.com.

PMID: 35381217
PMCID: PMC8977370
DOI: 10.1016/j.amjms.2022.03.007

Review

Hyperlipidemia, COVID-19 and acute pancreatitis: A tale of three entities

Qiuyi Tang et al. Am J Med Sci. 2022 Sep.

. 2022 Sep;364(3):257-263.

doi: 10.1016/j.amjms.2022.03.007. Epub 2022 Apr 4.

Authors

Qiuyi Tang¹, Lin Gao², Zhihui Tong³, Weiqin Li⁴

Affiliations

¹ Medical School, Southeast University, Nanjing, Jiangsu, China; Center of Severe Acute Pancreatitis (CSAP), Department of Intensive Care Unit, Jinling Hospital, Nanjing, Jiangsu, China.
² Center of Severe Acute Pancreatitis (CSAP), Department of Intensive Care Unit, Jinling Hospital, Nanjing, Jiangsu, China.
³ Center of Severe Acute Pancreatitis (CSAP), Department of Intensive Care Unit, Jinling Hospital, Nanjing, Jiangsu, China. Electronic address: njzyantol@hotmail.com.
⁴ Medical School, Southeast University, Nanjing, Jiangsu, China; Center of Severe Acute Pancreatitis (CSAP), Department of Intensive Care Unit, Jinling Hospital, Nanjing, Jiangsu, China. Electronic address: njzy_pancrea@163.com.

PMID: 35381217
PMCID: PMC8977370
DOI: 10.1016/j.amjms.2022.03.007

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the ongoing pandemic of coronavirus disease 2019 (COVID-19), which presented as not only respiratory symptoms, but various digestive manifestations including pancreatic injury and acute pancreatitis (AP). The underlying mechanism is still unclear. Hypertriglyceridemia has become one of the leading causes of AP in recent years and hyperlipidemia is highly reported in COVID-19 cases. The current narrative review aimed to explore the associations between AP, COVID-19 and hyperlipidemia. Substantial cases of COVID-19 patients complicated with AP were reported, while the incidence of AP in the COVID-19 population was relatively low. Hyperlipidemia was common in COVID-19 patients with a pooled incidence of 32.98%. Hyperlipidemia could be a mediating factor in the pathogenesis of AP in COVID-19 patients. Further studies are warranted to clarify the relationship among AP, lipid metabolism disorders and COVID-19.

Keywords: Acute pancreatitis; COVID-19; Hyperlipidemia; Pancreatic injury; SARS-CoV-2.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that there is no conflict of interest regarding the research, authorship, and/or publication of this paper.

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[1] Gupta A., Madhavan M.V., Sehgal K., et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020;26(7):1017–1032. doi: 10.1038/s41591-020-0968-3. - DOI - PMC - PubMed

[2] Gupta A., Madhavan M.V., Sehgal K., et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020;26(7):1017–1032. doi: 10.1038/s41591-020-0968-3. - DOI - PMC - PubMed

[3] Berlin D.A., Gulick R.M., Martinez F.J. Severe COVID-19. N Engl J Med. 2020;383(25):2451–2460. doi: 10.1056/NEJMcp2009575. - DOI - PubMed

[4] Berlin D.A., Gulick R.M., Martinez F.J. Severe COVID-19. N Engl J Med. 2020;383(25):2451–2460. doi: 10.1056/NEJMcp2009575. - DOI - PubMed

[5] van Dijk S.M., Hallensleben N.D.L., van Santvoort H.C., et al. Acute pancreatitis: recent advances through randomised trials. Gut. 2017;66(11):2024–2032. doi: 10.1136/gutjnl-2016-313595. - DOI - PubMed

[6] van Dijk S.M., Hallensleben N.D.L., van Santvoort H.C., et al. Acute pancreatitis: recent advances through randomised trials. Gut. 2017;66(11):2024–2032. doi: 10.1136/gutjnl-2016-313595. - DOI - PubMed

[7] Wifi M.N., Nabil A., Awad A., Eltatawy R. COVID-induced pancreatitis: case report. Egypt J Intern Med. 2021;33(1):10. doi: 10.1186/s43162-021-00039-y. - DOI - PMC - PubMed

[8] Wifi M.N., Nabil A., Awad A., Eltatawy R. COVID-induced pancreatitis: case report. Egypt J Intern Med. 2021;33(1):10. doi: 10.1186/s43162-021-00039-y. - DOI - PMC - PubMed

[9] Tollard C., Champenois V., Delemer B., Carsin-Vu A., Barraud S. An inaugural diabetic ketoacidosis with acute pancreatitis during COVID-19. Acta Diabetol. 2021;58(3):389–391. doi: 10.1007/s00592-020-01624-3. - DOI - PMC - PubMed

[10] Tollard C., Champenois V., Delemer B., Carsin-Vu A., Barraud S. An inaugural diabetic ketoacidosis with acute pancreatitis during COVID-19. Acta Diabetol. 2021;58(3):389–391. doi: 10.1007/s00592-020-01624-3. - DOI - PMC - PubMed

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Hyperlipidemia, COVID-19 and acute pancreatitis: A tale of three entities

Affiliations

Hyperlipidemia, COVID-19 and acute pancreatitis: A tale of three entities

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