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Review
. 2022 Mar 6;56(3):386-390.
doi: 10.3760/cma.j.cn112150-20210729-00728.

[Research progress on the incidence and economic burden of herpes zoster disease in immunocompromised population]

[Article in Chinese]
Y Y Yang  1 , C X Fu  1
Affiliations
Review

[Research progress on the incidence and economic burden of herpes zoster disease in immunocompromised population]

[Article in Chinese]
Y Y Yang et al. Zhonghua Yu Fang Yi Xue Za Zhi. .

Abstract
in English, Chinese

With the increase of age or the impairment of immune function, the specific cellular immune level against varicella zoster virus (VZV) in the body decreases, and the latent VZV in the ganglion can be reactivated to cause herpes zoster (HZ). HZ and its main complication postherpetic neuralgia (PHN) can seriously affect the quality of life of patients. The immunocompromised (IC) population is more prone to HZ than the immunocompetent population due to diseases and therapeutic drugs. This paper reviews the incidence, risk factor and economic burden of HZ in IC population with special health status, to provide ideas for research and adjustment of immunization strategies in the future.

随着年龄增长或机体免疫功能受损，机体针对水痘-带状疱疹病毒（VZV）特异性细胞免疫水平降低，潜伏于神经节内的VZV可经再激活而发生带状疱疹（HZ）。HZ及其主要并发症带状疱疹后神经痛（PHN）可严重影响患者的生活质量。免疫功能低下（IC）人群因疾病和治疗药物影响，较免疫功能正常者更易发生HZ。本研究针对IC这一特殊健康状态人群HZ的发病水平、危险因素和经济负担进行综述，为今后深入开展相关研究、调整疫苗免疫策略提供思路。.

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