Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan 13:41:37.
doi: 10.11604/pamj.2022.41.37.32553. eCollection 2022.

Prevalence and correlates of hypothyroidism in pregnancy: a cross-sectional study at Bouget General Hospital, Ivory Coast

Valéry Katché Adoueni  1 , Auguste Jean-Claude Azoh  1 , Ethmonia Kouame  1 , David Guanga Meless  2   3 , Pascal Sibailly  1 , Augustin Koudou Derbe  1 , Marie-Chantal N Guessan  1 , Koffi Benjamin Dzade  1 , Simplice Koffi  1 , Théodore Kouakou  1 , Lydie Viviane Arra  1 , Yolande Ouattara  1
Affiliations

Prevalence and correlates of hypothyroidism in pregnancy: a cross-sectional study at Bouget General Hospital, Ivory Coast

Valéry Katché Adoueni et al. Pan Afr Med J. .

Abstract

Introduction: several adverse pregnancy outcomes have been reported in gestations with associated hypothyroidism. The prevalence of hypothyroidism has not been frequently reported in Black Africans. This study sorts to report the prevalence and associated factors of hypothyroidism in Black African pregnant women.

Methods: this was a hospital-based cross-sectional study, including all pregnant women attending the gynecologic unit of Bouget General Hospital Abidjan. Serum thyroid-stimulating hormone and T4 were obtained from all participants and analyzed using a fluorescent Immunochemistry assay. Data were analyzed using R version 4.05. Univariable and multivariable logistic regression was used to assess factors associated with hypothyroidism and statistical significance considered as p < 0.05.

Results: overall there were 693 participants, mean age of 28.1(SD 6.4) years with an average gestational age of 24.1 (SD 8) weeks, and a majority of study participants were in the second trimester of gestation. The prevalence of hypothyroidism was 12.1% (n = 84) (10.8% subclinical hypothyroidism and 1.3% clinical hypothyroidism) whereas 1.9% (n = 13) had hyperthyroidism. In addition, patients with reported type 1 diabetes mellitus had an increased risk of hypothyroidism (aOR: 12.6, 95% CI 1.9-100.8; p ≤ 0.01).

Conclusion: this study revealed a high prevalence of hypothyroidism, though mostly in the subclinical form. Further research is warranted to confirm these findings which may have implications on early screening of hypothyroidism in black African women.

Keywords: Black women; Thyroid disorders; hypothyroidism; pregnancy.

PubMed Disclaimer

Figures

Figure 1
Figure 1
flow chart of the study participants
See this image and copyright information in PMC

References

    1. Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, et al. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease during Pregnancy and the Postpartum, Thyroid. Mary Ann Liebert Inc. 2017 Mar;27(3):315–389. - PubMed
    1. Vanderpump MPJ. The epidemiology of thyroid disease. Br Med Bull. 2011;99:39–51. - PubMed
    1. Mahadik K, Choudhary P, Roy PK. Study of thyroid function in pregnancy, its feto-maternal outcome; a prospective observational study, BMC Pregnancy Childbirth. BMC Pregnancy and Childbirth. 2020 Dec 10;20(1):769. - PMC - PubMed
    1. Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med. 1999 Aug 19;341(8):549–55. - PubMed
    1. Moog NK, Entringer S, Heim C, Wadhwa PD, Kathmann N, Buss C. Influence of maternal thyroid hormones during gestation on fetal brain development. Neuroscience. 2017 Feb 7;342:68–100. - PMC - PubMed