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. 2021 Feb;6(1):3-10.
doi: 10.1177/2397198320924873. Epub 2020 Jun 8.

Overall mortality

Duncan F Moore  1 , Virginia D Steen  1
Affiliations

Overall mortality

Duncan F Moore et al. J Scleroderma Relat Disord. 2021 Feb.

Abstract

Systemic sclerosis is a highly morbid, complex autoimmune disease that is variable both in its phenotype and the attendant mortality driven by such manifestations. This review article synthesizes mortality data from the best available meta-analyses, subgroup analyses of single cohorts, and subjective comparisons of individual cohort studies, which in aggregate suggest that mortality in systemic sclerosis has been gradually improving over the past several decades. This review also summarizes the literature describing various risk factors for mortality in systemic sclerosis.

Keywords: Systemic sclerosis; mortality; review; risk factors; scleroderma.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Pokeerbux MR, Giovannelli J, Dauchet L, et al.. Survival and prognosis factors in systemic sclerosis: data of a French multicenter cohort, systematic review, and meta-analysis of the literature. Arthritis Res Ther 2019; 21(1): 86. - PMC - PubMed
    1. Lee YH. Overall and sex- and disease subtype-specific mortality in patients with systemic sclerosis: an updated meta-analysis. Z Rheumatol 2019; 78(2): 195–201. - PubMed
    1. Elhai M, Meune C, Avouac J, et al.. Trends in mortality in patients with systemic sclerosis over 40 years: a systematic review and meta-analysis of cohort studies. Rheumatology 2012; 51(6): 1017–1026. - PubMed
    1. Toledano E, Candelas G, Rosales Z, et al.. A meta-analysis of mortality in rheumatic diseases. Reumatol Clin 2012; 8(6): 334–341. - PubMed
    1. Rubio-Rivas M, Royo C, Simeon CP, et al.. Mortality and survival in systemic sclerosis: systematic review and meta-analysis. Semin Arthritis Rheum 2014; 44(2): 208–219. - PubMed