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Exemplified microtechnology-based cell culture models and microfluidic devices for liver physiology and liver…
FIG. 1.
Exemplified microtechnology-based cell culture models and microfluidic devices for liver physiology and liver diseases. (a) A liver organoid-on-a-chip system aimed at mimicking liver function and pathophysiology. (b) Sirius red and fast green staining of monoculture and coculture biochips from the article of Danoy et al. (c) Liver zonation recreated in a microfluidic device from the review of de Hoyos-Vega et al. (d) A 3D vascularized tumor model for cancer-specific characterization and drug dissemination from the review of Lam et al. (e) A high-throughput droplet microfluidic device for the generation of 3D liver microtissues from the review of Monckton et al. (f) Conceptual design of a liver–heart organoids-on-chip system. (a) Reproduced with permission from Gori et al., PLoS One 11, e0159729 (2016). Copyright 2016 Authors, licensed under a Creative Commons Attribution (CC BY) license; (b) reproduced with permission from Danoy et al., APL Bioeng. 5, 026104 (2021). Copyright 2021 AIP Publishing; (c) reproduced with permission from de Hoyos-Vega et al., APL Bioeng. 5, 041504 (2021). Copyright 2021 AIP Publishing; (d) reproduced with permission from Pavesi et al., JCI Insight 2(12), e89762 (2017). Copyright 2017 Authors, licensed under a Creative Commons Attribution (CC BY) license; (e) reproduced with permission from Kukla et al., Gene Expression 20(1), 1 (2020). Copyright 2020 Authors, licensed under the Creative Commons CC BY-NC-ND license; (f) reproduced with permission from Skardal et al., Sci. Rep. 7, 8837 (2017). Copyright 2017 Authors, licensed under a Creative Commons Attribution (CC BY) license.
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