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. 2022 Apr 5;15(1):128.
doi: 10.1186/s13104-022-06008-0.

Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity

Hanna Lee  1 , Young Sun Suh  2 , Sang-Il Lee  1 , Yun-Hong Cheon  1 , Mingyo Kim  1 , Hae Sook Noh  3 , Hyun-Ok Kim  4
Affiliations

Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity

Hanna Lee et al. BMC Res Notes. .

Abstract

Objective: Insulin-like growth factor (IGF)-1 participates in modulating immunity and inflammation. Its bioactivity is controlled by six IGF-binding proteins (IGFBP-1 to IGFBP-6). In particular, the IGFBP-3 level is reportedly linked to the disease activity of rheumatoid arthritis (RA), consistent with our previous study. Therefore, the present study aimed to reproduce the previous results.

Results: The serum IGFBP-3 level was not significantly different among the three groups according to disease activity based on the DAS28-ESR/CRP (p > 0.05) but was significantly different between the low- and high-disease-activity groups based on the DAS28-CRP (p = 0.036). Meanwhile, the interleukin-6 (IL-6) level moderately correlated with DAS28-CRP (Spearman's rho = 0.583, p < 0.001).

Keywords: Disease activity; Insulin-like growth factor binding protein-3; Insulin-like growth factor-1; Rheumatoid arthritis.

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Conflict of interest statement

The authors declare that they have no competing interests.

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