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. 2022 Jul 8;52(7):707-715.
doi: 10.1093/jjco/hyac043.

Findings from the first colorectal cancer screening among 103 542 individuals in Vietnam with systematic review of colorectal cancer screening programs in Asia-Pacific region

Chi Thi-Du Tran  1   2   3 , Mai Vu-Tuyet Nguyen  1 , Mo Thi Tran  1 , Thuy Thi-Van Tuong  1 , Quang Hong Tran  1 , Linh Cu Le  2 , Huong Thi-Thu Pham  4 , Nam Chi Bui  4 , Hien Huy Vu  4 , Tu Thi-Cam Nguyen  4 , Phuong Que Ta  4 , Hien Thi-Thu Ha  5 , Dung Tuan Trinh  5   6 , Hanh Thi-My Bui  5 , Dien Quang Trinh  5 , Khanh Van Nguyen  5 , Song Huu Le  7 , Khien Van Vu  8 , Thuan Van Tran  9   10 , Huong Thi-Thanh Tran  10 , Martha J Shrubsole  11 , Fei Ye  11 , Qiuyin Cai  11 , Wei Zheng  11 , Paolo Boffetta  12   13 , Xiao-Ou Shu  11 , Hung N Luu  14   15
Affiliations

Findings from the first colorectal cancer screening among 103 542 individuals in Vietnam with systematic review of colorectal cancer screening programs in Asia-Pacific region

Chi Thi-Du Tran et al. Jpn J Clin Oncol. .

Erratum in

  • Correction.
    [No authors listed] [No authors listed] Jpn J Clin Oncol. 2022 Nov 3;52(11):1358. doi: 10.1093/jjco/hyac156. Jpn J Clin Oncol. 2022. PMID: 36124846 Free PMC article. No abstract available.

Abstract

Background: Colorectal cancer is a leading cancer incidence and cause of death worldwide and in Vietnam. Although screening is considered an effective measure to prevent and control colorectal cancer, there is no such effort in Vietnam.

Methods: Between 01 January 2018 and 31 October 2019, a population-based colorectal cancer screening program was conducted in Hanoi, Vietnam. A health advocacy campaign and follow-up phone calls were used to enroll residents aged ≥40 years old to complete an immunochemical-fecal occult blood testing. Positive immunochemical-fecal occult blood testing was followed by a colonoscopy. We also conducted a systematic review of the colorectal cancer screening programs in the Asia-Pacific region that used similar approach by searching Ovid Medline and PubMed databases.

Results: During study period, 103 542 individuals among 672 742 eligible residents attended the screening of whom 81.5% participants finished immunochemical-fecal occult blood testing test and the positive rate was 6.1%. The coverage rate for immunochemical-fecal occult blood testing test was 11.9%. Among 2278 individuals who underwent colonoscopy, 3.5% were histologically diagnosed with cancer, 17.8% with advanced adenomas, and 23.1% with non-advanced adenomas. Males had significantly higher detection rate of advanced adenomas, cancer or ≥ two polyps/tumor than females (P < 0.0001). The systematic review showed that in two-step modality (i.e. immunochemical-fecal occult blood testing/fecal immunochemical test and colonoscopy), the test positive was from 4.1 to 10.6%. Once colonoscopy was performed subsequently, the rate of cancer among positive participants was from 1.7 to 16.4% and that of advanced adenomas was from 7.1 to 23.1%.

Conclusion: We showed that the two-step modality is a promising strategy for colorectal cancer screening in Vietnam that might apply to similar settings with limited resources.

Keywords: Vietnam; adenomas; colorectal cancer; colorectal polyps; screening.

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Figures

Figure 1
Figure 1
Work flow in the colorectal cancer screening program, Hanoi, Vietnam.
Figure 2
Figure 2
Flowchart for screening and eligibility evaluation process of the systematic review, colorectal cancer screening program in Asia-Pacific region.
Figure 3
Figure 3
FIT test positive results – a systematic review of Asia-Pacific region. aOne-specimen; bTwo-specimen.
Figure 4
Figure 4
Percentage of advanced adenomas and cancer among individuals with FIT test positive who underwent colonoscopy – a systematic review of Asia-Pacific region. Note: Study without data on advanced adenomas or cancer has data on one outcome only (i.e. either advanced adenomas or cancer) but not both outcomes. aOne-specimen; bTwo-specimen; c100 ng Hb/m; d75 ng Hb/m; e50 ng Hb/m.
See this image and copyright information in PMC

References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394–424. - PubMed
    1. GBD 2017 Colorectal Cancer Collaborators . The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017. Lancet Gastroenterol Hepatol 2019;4:913–33. - PMC - PubMed
    1. Hardy RG, Meltzer SJ, Jankowski JA. ABC of colorectal cancer. Molecular basis for risk factors. BMJ 2000;321:886–9. - PMC - PubMed
    1. Ferlay J, Colombet M, Soerjomataram I, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer 2019;144:1941–53. - PubMed
    1. Nguyen TP, Luu HN, Nguyen MVT, Tran MT, Tuong TTV, Tran CTD, Boffetta P. Attributable causes of cancer in Vietnam. JCO Glob Oncol 2020;6:195–204. - PMC - PubMed

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