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. 2023 Mar;133(3):506-511.
doi: 10.1002/lary.30128. Epub 2022 Apr 5.

Sinonasal inverted papilloma - malignant transformation and non-sinonasal malignancies

Sanna Viitasalo  1 , Taru Ilmarinen  1 , Leena-Maija Aaltonen  1 , Jaana Hagström  2   3 , Maija Hytönen  1 , Sari Hammarén-Malmi  1 , Petra Pietarinen  1 , Pia Järvenpää  1 , Teemu Kinnari  1 , Ahmed Geneid  1 , Markus Lilja  1
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Free article

Sinonasal inverted papilloma - malignant transformation and non-sinonasal malignancies

Sanna Viitasalo et al. Laryngoscope. 2023 Mar.
Free article

Abstract

Objectives: To assess malignant transformation rate, non-sinonasal malignancies, and factors contributing to recurrence in patients treated for sinonasal inverted papilloma (SNIP).

Study design: Retrospective study.

Methods: We retrospectively reviewed medical records of all patients treated for SNIP (n = 296) between the years 1984-2014 at Helsinki University Hospital. Data from the Finnish Cancer Registry confirmed the number of those patients with sinonasal and non-sinonasal malignancies.

Results: Only 2 of 296 (0.7%) patients primarily diagnosed with benign SNIP developed sinonasal cancer in a mean follow-up of 5.8 years. The most common non-sinonasal cancer sites were similar to those reported for the whole Finnish population. None of the patients presented with an HPV-associated non-sinonasal malignancy. The recurrence rate among patients who underwent attachment-oriented surgery was significantly lower compared to those operated on with other approaches (40.2% vs. 56.6%, p = 0.006). Dysplasia in SNIP was associated with a higher recurrence rate (p < 0.001).

Conclusions: Malignant transformation of SNIP was rare. Patients with SNIP were not prone to HPV-associated non-sinonasal malignancies. Endoscopic resection and attachment-oriented surgery have become predominant approaches in the treatment of SNIP; meanwhile, the total number of SNIP recurrences has decreased.

Level of evidence: 3 Laryngoscope, 133:506-511, 2023.

Keywords: inverted papilloma; operative treatment; sinonasal carcinoma; sinonasal neoplasm; sinonasal papilloma.

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References

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