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. 2022 Jun;37(6):1299-1304.
doi: 10.1002/mds.29009. Epub 2022 Apr 6.

Diabetes, Glycated Hemoglobin (HbA1c), and Neuroaxonal Damage in Parkinson's Disease (MARK-PD Study)

Merve Uyar  1 , Susanne Lezius  2 , Carsten Buhmann  1 , Monika Pötter-Nerger  1 , Robert Schulz  1 , Stephanie Meier  3 , Christian Gerloff  1 , Jens Kuhle #  3 , Chi-Un Choe #  1
Affiliations

Diabetes, Glycated Hemoglobin (HbA1c), and Neuroaxonal Damage in Parkinson's Disease (MARK-PD Study)

Merve Uyar et al. Mov Disord. 2022 Jun.

Abstract

Background: Diabetes is associated with incidence and prevalence of Parkinson's disease (PD). Furthermore, glycated hemoglobin (HbA1c) levels have been linked with motor function and progression.

Objectives: We evaluated the relationship between prevalent diabetes and HbA1c levels with serum neurofilament light chain (NfL) levels as marker of neuroaxonal damage.

Methods: NfL concentrations were analyzed with Simoa in serum of 195 PD patients with available HbA1c values. Motor (MDS-UPDRS III, Hoehn & Yahr [H&Y]) and cognitive (Montreal Cognitive Assessment [MoCA]) function was assessed and vascular comorbidities were documented from medical records.

Results: PD patients with prevalent diabetes had higher serum NfL levels and lower MoCA scores independent of age, body mass index (BMI), and vascular risk factors. Furthermore, diabetes was associated with higher H&Y stages in unadjusted and age/BMI-adjusted models. Higher HbA1c levels were associated with increased NfL in unadjusted and age/BMI-adjusted models.

Conclusions: In PD patients, diabetes and high HbA1c are associated with increased neuroaxonal damage and cognitive impairment. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson Movement Disorder Society.

Keywords: Simoa; glycemia; neurofilament.

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Comment in

  • Reply to: "Diabetes and Neuroaxonal Damage in Parkinson's Disease".
    Buhmann C, Pötter-Nerger M, Schulz R, Gerloff C, Kuhle J, Choe CU. Buhmann C, et al. Mov Disord. 2022 Jul;37(7):1569-1570. doi: 10.1002/mds.29064. Mov Disord. 2022. PMID: 35856728 No abstract available.
  • Diabetes and Neuroaxonal Damage in Parkinson's Disease.
    Vijiaratnam N, Lawton M, Real R, Heslegrave AJ, Guo T, Athauda D, Gandhi S, Girges C, Ben-Shlomo Y, Zetterberg H, Grosset DG, Morris HR, Foltynie T; PRoBaND Clinical Consortium. Vijiaratnam N, et al. Mov Disord. 2022 Jul;37(7):1568-1569. doi: 10.1002/mds.29067. Mov Disord. 2022. PMID: 35856732 Free PMC article. No abstract available.

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