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Meta-Analysis
. 2022 Jul;48(7):1888-1896.
doi: 10.1111/jog.15238. Epub 2022 Apr 5.

Adjuvant chemoradiotherapy versus chemotherapy alone in stage III endometrial cancer: A systematic review and meta-analysis

Guo Zhang  1 , He Li  1 , Zhao Tian  1 , Xiaoping Li  1 , Zhiqi Wang  1 , Xudong Liang  1 , Yue Wang  1 , Xiaoyan Shen  1 , Jianliu Wang  1
Affiliations
Meta-Analysis

Adjuvant chemoradiotherapy versus chemotherapy alone in stage III endometrial cancer: A systematic review and meta-analysis

Guo Zhang et al. J Obstet Gynaecol Res. 2022 Jul.

Abstract

Objective: To discuss the impact of chemoradiotherapy (CRT) on the survival of patients with stage III endometrial cancer (EC) compared with chemotherapy (CT) alone.

Methods: Articles involving adjuvant CRT versus CT on survival in stage III EC were retrieved from PubMed and EMBASE. Hazard ratios (HRs) of overall survival (OS) and relapse-free survival (RFS) were collected and pooled, and publication bias was measured by Begg's and Egger's test. Quality of researches was measured by the Newcastle-Ottawa scale and the modified Jadad scale.

Results: Eleven were included in the statistical analysis. A significant advantage of CRT over CT on OS was shown (HR 0.59, 95% CI 0.49-0.70). Further subgroup analysis suggested the advantage was mostly associated with stage IIIC (HR 0.63, 95% CI 0.52, 0.76]). A similar result favoring CRT was also reached on RFS (HR 0.66, 95% CI 0.47-0.93). No significant publication bias was observed.

Conclusion: CRT was associated with a better OS and RFS than CT alone in stage III EC patients.

Keywords: chemoradiotherapy; chemotherapy; endometrial cancer; overall survival; relapse-free survival.

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