Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul 11;61(28):e202201485.
doi: 10.1002/anie.202201485. Epub 2022 May 12.

Hydrogen-Bonded Organic Framework (HOF)-Based Single-Neural Stem Cell Encapsulation and Transplantation to Remodel Impaired Neural Networks

Dongqin Yu  1   2 , Haochen Zhang  1   2 , Zhenqi Liu  1   2 , Chun Liu  1   2 , Xiubo Du  3 , Jinsong Ren  1   2 , Xiaogang Qu  1   2
Affiliations

Hydrogen-Bonded Organic Framework (HOF)-Based Single-Neural Stem Cell Encapsulation and Transplantation to Remodel Impaired Neural Networks

Dongqin Yu et al. Angew Chem Int Ed Engl. .

Abstract

Herein we present a new way to encapsulate neural stem cells (NSCs) by using hydrogen-bonded organic frameworks (HOFs) to overcome the common causes of low therapeutic efficacy during NSC transplantation: 1) loss of fundamental stem cell properties, "stemness", before transplantation, 2) cytomembrane damage during transplantation, and 3) apoptosis due to oxidative stress after transplantation. Porous carbon nanospheres (PCNs) are doped into the HOF shell during the process of mineralization to endow the cellular exoskeletons with hierarchical hydrogen bonds, and the ability to resist oxidative stress due to the catalase and superoxide dismutase-like activities of PCN. Under NIR-II irradiation, thermal-responsive hydrogen bonds dissociate to release NSCs. Stereotactic transplanting encapsulated NSC into the brain of an Alzheimer's disease (AD) mouse model further verifies that our design can enhance NSC viability, promote neurogenesis, and ameliorate cognitive impairment. As the first example of using HOFs to encapsulate NSCs, this work may inspire the design of HOF-based exoskeletons to ameliorate neurogenesis and cognitive behavioral symptoms associated with AD.

Keywords: Cell Encapsulation; Cell Transplantation; Hydrogen-Bonded Organic Frameworks; Neurogenesis; Stem Cells.

PubMed Disclaimer

References

    1. None
    1. J. G. Roth, M. S. Huang, T. L. Li, V. R. Feig, Y. Jiang, B. Cui, H. T. Greely, Z. Bao, S. P. Paşca, S. C. Heilshorn, Nat. Rev. Neurosci. 2021, 22, 593-615;
    1. L. M. Marquardt, V. M. Doulames, A. T. Wang, K. Dubbin, R. A. Suhar, M. J. Kratochvil, Z. A. Medress, G. W. Plant, S. C. Heilshorn, Sci. Adv. 2020, 6, eaaz1039;
    1. O. Lindvall, Z. Kokaia, Nature 2006, 441, 1094-1096;
    1. F.-J. Müller, E. Y. Snyder, J. F. Loring, Nat. Rev. Neurosci. 2006, 7, 75-84;

Publication types

LinkOut - more resources