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Comment
. 2022 Apr 5;34(4):503-505.
doi: 10.1016/j.cmet.2022.03.007.

Sugar addiction: An Achilles' heel of auto-immune diseases?

Dietmar M W Zaiss  1 , Paul J Coffer  2
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Sugar addiction: An Achilles' heel of auto-immune diseases?

Dietmar M W Zaiss et al. Cell Metab. .
Free article

Abstract

In this issue of Cell Metabolism, Hochrein et al. identify a metabolic checkpoint controlling the transcriptional programming of effector CD4+ T cells. The authors show that GLUT3-mediated glucose import and ACLY-dependent acetyl-CoA generation control histone acetylation and, hence, the epigenetic imprinting of effector gene expression in differentiated effector CD4+ T cells. These findings suggest a novel therapeutic target for inflammation-associated diseases.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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