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Comment
. 2022 Apr 5;34(4):508-510.
doi: 10.1016/j.cmet.2022.03.004.

Making a sPLAsh: The expanding repertoire of EV signaling

Guoping Li  1 , Saumya Das  2
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Making a sPLAsh: The expanding repertoire of EV signaling

Guoping Li et al. Cell Metab. .
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Abstract

Extracellular vesicles (EVs) and their cargo act as signaling moieties by transferring their cargo to recipient cells, thereby mediating intercellular communication in complex tissue environments such as the tumor microenvironment. In the accompanying paper, Kudo et al. describe the interaction between tumor EVs and soluble phospholipase released by macrophages, leading to the remodeling of EV membranes and the release of lipid mediators that facilitate tumor growth by inducing an immune-tolerant phenotype.

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Conflict of interest statement

Declarations of interests S.D. is a founding member of Long QT Therapeutics and Switch Therapeutics and has a research grant from Abbott, none of which are relevant for this manuscript.

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