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Comment
. 2022 Apr 5;34(4):513-515.
doi: 10.1016/j.cmet.2022.03.008.

Ketones regulate endothelial homeostasis

Gary D Lopaschuk  1 , David A Hess  2 , Subodh Verma  3
Affiliations
Comment

Ketones regulate endothelial homeostasis

Gary D Lopaschuk et al. Cell Metab. .

Abstract

In a recent paper in EMBO Molecular Medicine, Weis et al. reveal that cardiac endothelial cells can oxidize ketone bodies, which enhances cell proliferation, migration, and vessel sprouting. Furthermore, increasing ketone body levels with a ketogenic diet can increase endothelial cell proliferation and prevent blood vessel rarefication in hypertrophied mouse hearts. This suggests that increasing endothelial cell ketone oxidation has potential in treating heart failure.

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Conflict of interest statement

Declaration of interests S.V. holds a Tier 1 Canada Research Chair in Cardiovascular Surgery and reports receiving research grants and/or speaking honoraria from Amarin, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, EOCI Pharmacomm Ltd, HLS Therapeutics, Janssen, Novartis, Novo Nordisk, Pfizer, PhaseBio, Sanofi, Sun Pharmaceuticals, and the Toronto Knowledge Translation Working Group. He is the President of the Canadian Medical and Surgical Knowledge Translation Research Group, a federally incorporated not-for-profit physician organization. G.D.L. reports receiving research grants and/or speaking honoraria from Applied Therapeutics, Boehringer Ingelheim, Servier, Janssen, Sanofi, and Novartis.

Comment on

  • Ketone body oxidation increases cardiac endothelial cell proliferation.
    Weis EM, Puchalska P, Nelson AB, Taylor J, Moll I, Hasan SS, Dewenter M, Hagenmüller M, Fleming T, Poschet G, Hotz-Wagenblatt A, Backs J, Crawford PA, Fischer A. Weis EM, et al. EMBO Mol Med. 2022 Apr 7;14(4):e14753. doi: 10.15252/emmm.202114753. Epub 2022 Feb 18. EMBO Mol Med. 2022. PMID: 35179309 Free PMC article.

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