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. 2022 Mar 21:13:842008.
doi: 10.3389/fimmu.2022.842008. eCollection 2022.

Immune Cell Proinflammatory Microenvironment and Androgen-Related Metabolic Regulation During Benign Prostatic Hyperplasia in Aging

Dehong Cao  1   2 , Ruonan Sun  1   2   3 , Lei Peng  4 , Jinze Li  1   2 , Yin Huang  1   2   3 , Zeyu Chen  1   2   3 , Bo Chen  1   2   3 , Jin Li  1   2   3 , Jianzhong Ai  1   2 , Lu Yang  1   2 , Liangren Liu  1   2 , Qiang Wei  1   2
Affiliations

Immune Cell Proinflammatory Microenvironment and Androgen-Related Metabolic Regulation During Benign Prostatic Hyperplasia in Aging

Dehong Cao et al. Front Immunol. .

Abstract

To review the role of inflammation in the occurrence and development of benign prostatic hyperplasia (BPH), we searched PubMed for the latest published articles up to February 2021 using the following key words: "benign prostatic hyperplasia", "inflammation", "pathogenesis" and "disease development". Articles were obtained and reviewed to provide a systematic review of the current progress of the role of inflammation in the pathogenesis and progression of BPH. Inflammation contributes to the initiation and maintenance of unregulated cell proliferation and is closely related to the occurrence and development of BPH. Its action pathways include tissue damage and subsequent chronic healing, autoimmunity, and coaction with androgens. During the progression of inflammation, macrophages, interleukin-8 (IL-8), interleukin-1 (IL-1) and other inflammatory-related substances aggregate locally and cause BPH through various biochemical pathways. At the same time, BPH can also counteract inflammation to expand its scope and aggravate the situation. Inflammation can independently affect the development of BPH in a variety of ways, and it can also interact with androgens. In the course of treatment, early intervention in the occurrence and development of inflammation in prostate tissue can slow down the progression of BPH. The combination of standard therapies and anti-inflammatory measures may provide valuable new ideas for the treatment of BPH.

Keywords: aging; benign prostatic hyperplasia; disease progression; inflammation; pathogenesis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic diagram of the interaction between prostate cells and related cytokines 1.
Figure 2
Figure 2
Schematic diagram of the interaction between prostate cells and related cytokines 2.
See this image and copyright information in PMC

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