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. 2021 Dec 1:2:741135.
doi: 10.3389/falgy.2021.741135. eCollection 2021.

Association Between Asthma and Migraine: A Systematic Review and Meta-Analysis of Observational Studies

Lin-Lin Kang  1 , Pei-En Chen  2   3 , Tao-Hsin Tung  4 , Ching-Wen Chien  1
Affiliations

Association Between Asthma and Migraine: A Systematic Review and Meta-Analysis of Observational Studies

Lin-Lin Kang et al. Front Allergy. .

Abstract

Objectives: The purpose of this study was to determine the association between asthma and migraine and assess the risk for migraine in patients with asthma. Methods: We systematically searched the Cochrane Library, PubMed, Medical Literature Analysis and Retrieval System Online (MEDLINE), and Excerpta Medica dataBASE (EMBASE) databases from inception to September 26, 2021, for indexed observational studies that examined either the odds or risk of migraine in subjects with asthma. The qualities of the included studies were evaluated using the Newcastle-Ottawa Scale. A random-effects meta-analysis was performed to calculate the odds ratio for case-control and cross-sectional studies and the risk ratio for cohort studies. Results: Seven observational studies (four cross-sectional and three cohort studies) with a total of 549,534 study subjects were included in this systematic review and meta-analysis and selected for data extraction. Four articles were considered to be of moderate quality; other studies were considered to be of high quality. Asthma was associated with increased odds (OR, 1.85; 95%CI, 1.39-2.45) and risk of migraine (RR, 1.70; 95%CI, 1.52-1.90). Conclusions: The available evidence that supports the existence of an association between asthma and migraine is limited. Clinicians should be aware that patients with asthma show both increased prevalence and incidence of migraine. Further studies are warranted to further clarify the relationship between asthma and migraine. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=185881, identifier: CRD42020185881.

Keywords: association; asthma; meta-analysis; migraine; risk; systematic review.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) study flow chart.
Figure 2
Figure 2
Risk of migraine in patients with asthma in the cohort studies.
Figure 3
Figure 3
Odds of migraine in patients with asthma in the case-control and cross-sectional studies.
See this image and copyright information in PMC

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