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Clinical Trial
. 1986 Dec;143(12):1603-5.
doi: 10.1176/ajp.143.12.1603.

Paradoxical effects of amitriptyline on borderline patients

P H Soloff, A George, R S Nathan, P M Schulz, J M Perel
Clinical Trial

Paradoxical effects of amitriptyline on borderline patients

P H Soloff et al. Am J Psychiatry. 1986 Dec.

Abstract

A paradoxical increase in suicide threats, paranoid ideation, and demanding and assaultive behavior occurred among 15 borderline inpatients receiving amitriptyline in a double-blind study. This pattern differed significantly from that of 14 nonresponding patients receiving placebo.

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