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. 2022 Nov 8;6(21):5702-5706.
doi: 10.1182/bloodadvances.2021006498.

MGUS and clonal hematopoiesis show unrelated clinical and biological trajectories in an older population cohort

Matteo Claudio Da Vià  1   2 , Marta Lionetti  1   2 , Alessio Marella  1   2 , Antonio Matera  1   2 , Erica Travaglino  3 , Elena Signaroldi  1 , Alessia Antonella Galbussera  4 , Ugo Lucca  4 , Sara Mandelli  4 , Emma Riva  4 , Mauro Tettamanti  4 , Loredana Pettine  2 , Alessandra Pompa  2 , Luca Baldini  1   2 , Antonino Neri  1   2 , Matteo Giovanni Della Porta  3   5 , Niccolò Bolli  1   2
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MGUS and clonal hematopoiesis show unrelated clinical and biological trajectories in an older population cohort

Matteo Claudio Da Vià et al. Blood Adv. .

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) and clonal hematopoiesis (CH) are 2 preclinical clonal expansions of hematopoietic cells whose prevalence rises with age, reaching almost 10% in people of aged 70 years and older. The increased risk of myeloid malignancies in patients with myeloma is well defined, and the study of the association between CH and MGUS could help explain this phenomenon. Here, we analyzed a fully clinically annotated dataset of 777 older subjects (median age, 91 years) previously screened for prevalence of CH. The prevalence of MGUS and CH was 9.6% and 17.3%, respectively. We detected CH in 9.7% of the patients with MGUS and MGUS in 5.5% of the patients with CH. We did not find a significant correlation between the presence of MGUS and CH. Furthermore, the 2 conditions showed a differential association with clinical and laboratory covariates, suggesting that MGUS and CH may represent age-associated unrelated clonal drifts of hematopoietic cells. Confirmatory studies are needed to assess the relevance of CH in plasma cell disorders. This trial was registered at www.clinicaltrials.gov as #NCT03907553.

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Conflict of interest statement

Conflict-of-interest disclosure: N.B. received honoraria from Celgene, Amgen and Janssen. The other authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
Forest plots of multivariate analyses to determine the possible association between MGUS and CH. (A) Forest plot using CH as independent variable. (B) Forest plot using MGUS as independent variable. CI, confidence interval; OR, odds ratio.
See this image and copyright information in PMC

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