Practice Guideline
doi: 10.1016/j.hrthm.2022.03.1225.
Epub 2022 Apr 4.
European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) Expert Consensus Statement on the State of Genetic Testing for Cardiac Diseases
Arthur A M Wilde
1
, Christopher Semsarian
2
, Manlio F Márquez
3
, Alireza Sepehri Shamloo
4
, Michael J Ackerman
5
, Euan A Ashley
6
, Eduardo Back Sternick
7
, Héctor Barajas-Martinez
8
, Elijah R Behr
9
, Connie R Bezzina
10
, Jeroen Breckpot
11
, Philippe Charron
12
, Priya Chockalingam
13
, Lia Crotti
14
, Michael H Gollob
15
, Steven Lubitz
16
, Naomasa Makita
17
, Seiko Ohno
18
, Martín Ortiz-Genga
19
, Luciana Sacilotto
20
, Eric Schulze-Bahr
21
, Wataru Shimizu
22
, Nona Sotoodehnia
23
, Rafik Tadros
24
, James S Ware
25
, David S Winlaw
26
, Elizabeth S Kaufman
27
; Document Reviewers; Takeshi Aiba
28
, Andreas Bollmann
29
, Jong-Il Choi
30
, Aarti Dalal
31
, Francisco Darrieux
32
, John Giudicessi
33
, Mariana Guerchicoff
34
, Kui Hong
35
, Andrew D Krahn
36
, Ciorsti MacIntyre
37
, Judith A Mackall
38
, Lluís Mont
39
, Carlo Napolitano
40
, Juan Pablo Ochoa
41
, Petr Peichl
42
, Alexandre C Pereira
43
, Peter J Schwartz
44
, Jon Skinner
45
, Christoph Stellbrink
46
, Jacob Tfelt-Hansen
47
, Thomas Deneke
48
Affiliations
Affiliations
- 1 Heart Centre, Department of Cardiology, Amsterdam Universitair Medische Centra, Amsterdam, location AMC, The Netherlands. Electronic address: a.a.wilde@amsterdamumc.nl.
- 2 Agnes Ginges Centre for Molecular Cardiology at Centenary Institute, University of Sydney, Sydney, Australia. Electronic address: Christopher.semsarian@sydney.edu.au.
- 3 Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, Mexico; and Member of the Latin American Heart Rhythm Society (LAHRS). Electronic address: manlio.marquez@gmail.com.
- 4 Department of Electrophysiology, Heart Center at University of Leipzig, Leipzig, Germany.
- 5 Departments of Cardiovascular Medicine, Pediatric and Adolescent Medicine, and Molecular Pharmacology & Experimental Therapeutics; Divisions of Heart Rhythm Services and Pediatric Cardiology; Windland Smith Rice Genetic Heart Rhythm Clinic and Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN, USA.
- 6 Department of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
- 7 Arrhythmia and Electrophysiology Unit, Biocor Institute, Minas Gerais, Brazil; and Member of the Latin American Heart Rhythm Society (LAHRS).
- 8 Cardiovascular Research, Lankenau Institute of Medical Research, Wynnewood, PA, USA.
- 9 Cardiovascular Clinical Academic Group, Institute of Molecular and Clinical Sciences, St. George's, University of London; St. George's University Hospitals NHS Foundation Trust, London, UK; Mayo Clinic Healthcare, London.
- 10 Amsterdam UMC Heart Center, Department of Experimental Cardiology, Amsterdam, The Netherlands.
- 11 Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium.
- 12 Sorbonne Université, APHP, Centre de Référence des Maladies Cardiaques Héréditaires, ICAN, Inserm UMR1166, Hôpital Pitié-Salpêtrière, Paris, France.
- 13 Cardiac Wellness Institute, Chennai, India.
- 14 Center for Cardiac Arrhythmias of Genetic Origin, Istituto Auxologico Italiano, IRCCS, Milan, Italy; Cardiomyopathy Unit and Cardiac Rehabilitation Unit, San Luca Hospital, Istituto Auxologico Italiano, IRCCS, Milan, Italy; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
- 15 Inherited Arrhythmia and Cardiomyopathy Program, Division of Cardiology, University of Toronto, Toronto, ON, Canada.
- 16 Cardiac Arrhythmia Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
- 17 National Cerebral and Cardiovascular Center, Research Institute, Suita, Japan.
- 18 Department of Bioscience and Genetics, National Cerebral and Cardiovascular Center, Suita, Japan.
- 19 Clinical Department, Health in Code, A Coruña, Spain; and Member of the Latin American Heart Rhythm Society (LAHRS).
- 20 Arrhythmia Unit, Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil; and Member of the Latin American Heart Rhythm Society (LAHRS).
- 21 Institute for Genetics of Heart Diseases, University Hospital Münster, Münster, Germany.
- 22 Department of Cardiovascular Medicine, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
- 23 Cardiovascular Health Research Unit, Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
- 24 Cardiovascular Genetics Center, Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, Canada.
- 25 National Heart and Lung Institute and MRC London Institute of Medical Sciences, Imperial College London, London, UK; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
- 26 Cincinnati Children's Hospital Medical Centre, University of Cincinnati, Cincinnati, OH, USA.
- 27 Metrohealth Medical Center, Case Western Reserve University, Cleveland, OH, USA. Electronic address: ekaufman@metrohealth.org.
- 28 Department of Clinical Laboratory Medicine and Genetics, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
- 29 Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany; Leipzig Heart Institute, Leipzig Heart Digital, Leipzig, Germany.
- 30 Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
- 31 Department of Pediatrics, Division of Cardiology, Vanderbilt University School of Medicine, Nashville, TN, USA.
- 32 Arrhythmia Unit, Instituto do Coração, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
- 33 Department of Cardiovascular Medicine (Divisions of Heart Rhythm Services and Circulatory Failure and the Windland Smith Rice Genetic Heart Rhythm Clinic), Mayo Clinic, Rochester, MN, USA.
- 34 Division of Pediatric Arrhythmia and Electrophysiology, Italian Hospital of Buenos Aires, Buenos Aires, Argentina.
- 35 Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
- 36 Division of Cardiology, University of British Columbia, Vancouver, Canada.
- 37 Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Windland Smith Rice Genetic Heart Rhythm Clinic, Mayo Clinic, Rochester, MN, USA.
- 38 Center for Cardiac Electrophysiology and Pacing, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
- 39 Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigacion Biomedica en Red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
- 40 Molecular Cardiology, Istituti Clinici Scientifici Maugeri, IRCCS, Pavia, Italy; Department of Molecular Medicine, University of Pavia, Pavia, Italy.
- 41 Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro, Madrid, Spain; Centro de Investigacion Biomedica en Red en Enfermedades Cariovasculares (CIBERCV), Madrid, Spain.
- 42 Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
- 43 Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo Medical School, São Paulo 05403-000, Brazil; Hipercol Brasil Program, São Paulo, Brazil.
- 44 Center for Cardiac Arrhythmias of Genetic Origin, Istituto Auxologico Italiano, IRCCS, Milan, Italy.
- 45 Sydney Childrens Hospital Network, University of Sydney, Sydney, Australia.
- 46 Department of Cardiology and Intensive Care Medicine, University Hospital Campus Klinikum Bielefeld, Bielefeld, Germany.
- 47 The Department of Cardiology, the Heart Centre, Copenhagen University Hospital, Rigshopitalet, Copenhagen, Denmark; Section of Genetics, Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Denmark.
- 48 Heart Center Bad Neustadt, Bad Neustadt a.d. Saale, Germany.
- PMID: 35390533
- DOI: 10.1016/j.hrthm.2022.03.1225
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Practice Guideline
European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) Expert Consensus Statement on the State of Genetic Testing for Cardiac Diseases
Arthur A M Wilde et al.
Heart Rhythm.
2022 Jul.
Free article
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doi: 10.1016/j.hrthm.2022.03.1225.
Epub 2022 Apr 4.
Authors
Arthur A M Wilde
1
, Christopher Semsarian
2
, Manlio F Márquez
3
, Alireza Sepehri Shamloo
4
, Michael J Ackerman
5
, Euan A Ashley
6
, Eduardo Back Sternick
7
, Héctor Barajas-Martinez
8
, Elijah R Behr
9
, Connie R Bezzina
10
, Jeroen Breckpot
11
, Philippe Charron
12
, Priya Chockalingam
13
, Lia Crotti
14
, Michael H Gollob
15
, Steven Lubitz
16
, Naomasa Makita
17
, Seiko Ohno
18
, Martín Ortiz-Genga
19
, Luciana Sacilotto
20
, Eric Schulze-Bahr
21
, Wataru Shimizu
22
, Nona Sotoodehnia
23
, Rafik Tadros
24
, James S Ware
25
, David S Winlaw
26
, Elizabeth S Kaufman
27
; Document Reviewers; Takeshi Aiba
28
, Andreas Bollmann
29
, Jong-Il Choi
30
, Aarti Dalal
31
, Francisco Darrieux
32
, John Giudicessi
33
, Mariana Guerchicoff
34
, Kui Hong
35
, Andrew D Krahn
36
, Ciorsti MacIntyre
37
, Judith A Mackall
38
, Lluís Mont
39
, Carlo Napolitano
40
, Juan Pablo Ochoa
41
, Petr Peichl
42
, Alexandre C Pereira
43
, Peter J Schwartz
44
, Jon Skinner
45
, Christoph Stellbrink
46
, Jacob Tfelt-Hansen
47
, Thomas Deneke
48
Affiliations
- 1 Heart Centre, Department of Cardiology, Amsterdam Universitair Medische Centra, Amsterdam, location AMC, The Netherlands. Electronic address: a.a.wilde@amsterdamumc.nl.
- 2 Agnes Ginges Centre for Molecular Cardiology at Centenary Institute, University of Sydney, Sydney, Australia. Electronic address: Christopher.semsarian@sydney.edu.au.
- 3 Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, Mexico; and Member of the Latin American Heart Rhythm Society (LAHRS). Electronic address: manlio.marquez@gmail.com.
- 4 Department of Electrophysiology, Heart Center at University of Leipzig, Leipzig, Germany.
- 5 Departments of Cardiovascular Medicine, Pediatric and Adolescent Medicine, and Molecular Pharmacology & Experimental Therapeutics; Divisions of Heart Rhythm Services and Pediatric Cardiology; Windland Smith Rice Genetic Heart Rhythm Clinic and Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN, USA.
- 6 Department of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
- 7 Arrhythmia and Electrophysiology Unit, Biocor Institute, Minas Gerais, Brazil; and Member of the Latin American Heart Rhythm Society (LAHRS).
- 8 Cardiovascular Research, Lankenau Institute of Medical Research, Wynnewood, PA, USA.
- 9 Cardiovascular Clinical Academic Group, Institute of Molecular and Clinical Sciences, St. George's, University of London; St. George's University Hospitals NHS Foundation Trust, London, UK; Mayo Clinic Healthcare, London.
- 10 Amsterdam UMC Heart Center, Department of Experimental Cardiology, Amsterdam, The Netherlands.
- 11 Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium.
- 12 Sorbonne Université, APHP, Centre de Référence des Maladies Cardiaques Héréditaires, ICAN, Inserm UMR1166, Hôpital Pitié-Salpêtrière, Paris, France.
- 13 Cardiac Wellness Institute, Chennai, India.
- 14 Center for Cardiac Arrhythmias of Genetic Origin, Istituto Auxologico Italiano, IRCCS, Milan, Italy; Cardiomyopathy Unit and Cardiac Rehabilitation Unit, San Luca Hospital, Istituto Auxologico Italiano, IRCCS, Milan, Italy; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
- 15 Inherited Arrhythmia and Cardiomyopathy Program, Division of Cardiology, University of Toronto, Toronto, ON, Canada.
- 16 Cardiac Arrhythmia Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
- 17 National Cerebral and Cardiovascular Center, Research Institute, Suita, Japan.
- 18 Department of Bioscience and Genetics, National Cerebral and Cardiovascular Center, Suita, Japan.
- 19 Clinical Department, Health in Code, A Coruña, Spain; and Member of the Latin American Heart Rhythm Society (LAHRS).
- 20 Arrhythmia Unit, Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil; and Member of the Latin American Heart Rhythm Society (LAHRS).
- 21 Institute for Genetics of Heart Diseases, University Hospital Münster, Münster, Germany.
- 22 Department of Cardiovascular Medicine, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
- 23 Cardiovascular Health Research Unit, Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
- 24 Cardiovascular Genetics Center, Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, Canada.
- 25 National Heart and Lung Institute and MRC London Institute of Medical Sciences, Imperial College London, London, UK; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
- 26 Cincinnati Children's Hospital Medical Centre, University of Cincinnati, Cincinnati, OH, USA.
- 27 Metrohealth Medical Center, Case Western Reserve University, Cleveland, OH, USA. Electronic address: ekaufman@metrohealth.org.
- 28 Department of Clinical Laboratory Medicine and Genetics, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
- 29 Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, Leipzig, Germany; Leipzig Heart Institute, Leipzig Heart Digital, Leipzig, Germany.
- 30 Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
- 31 Department of Pediatrics, Division of Cardiology, Vanderbilt University School of Medicine, Nashville, TN, USA.
- 32 Arrhythmia Unit, Instituto do Coração, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
- 33 Department of Cardiovascular Medicine (Divisions of Heart Rhythm Services and Circulatory Failure and the Windland Smith Rice Genetic Heart Rhythm Clinic), Mayo Clinic, Rochester, MN, USA.
- 34 Division of Pediatric Arrhythmia and Electrophysiology, Italian Hospital of Buenos Aires, Buenos Aires, Argentina.
- 35 Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
- 36 Division of Cardiology, University of British Columbia, Vancouver, Canada.
- 37 Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Windland Smith Rice Genetic Heart Rhythm Clinic, Mayo Clinic, Rochester, MN, USA.
- 38 Center for Cardiac Electrophysiology and Pacing, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
- 39 Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigacion Biomedica en Red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
- 40 Molecular Cardiology, Istituti Clinici Scientifici Maugeri, IRCCS, Pavia, Italy; Department of Molecular Medicine, University of Pavia, Pavia, Italy.
- 41 Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro, Madrid, Spain; Centro de Investigacion Biomedica en Red en Enfermedades Cariovasculares (CIBERCV), Madrid, Spain.
- 42 Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
- 43 Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo Medical School, São Paulo 05403-000, Brazil; Hipercol Brasil Program, São Paulo, Brazil.
- 44 Center for Cardiac Arrhythmias of Genetic Origin, Istituto Auxologico Italiano, IRCCS, Milan, Italy.
- 45 Sydney Childrens Hospital Network, University of Sydney, Sydney, Australia.
- 46 Department of Cardiology and Intensive Care Medicine, University Hospital Campus Klinikum Bielefeld, Bielefeld, Germany.
- 47 The Department of Cardiology, the Heart Centre, Copenhagen University Hospital, Rigshopitalet, Copenhagen, Denmark; Section of Genetics, Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Denmark.
- 48 Heart Center Bad Neustadt, Bad Neustadt a.d. Saale, Germany.
- PMID: 35390533
- DOI: 10.1016/j.hrthm.2022.03.1225
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