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. 2021 Dec 16;9(3):330-333.
doi: 10.1002/mdc3.13375. eCollection 2022 Apr.

Huntington's Disease Gene Hunters: An Expanding Tale

Anne E Rosser  1   2   3 , Lesley Jones  1
Affiliations

Huntington's Disease Gene Hunters: An Expanding Tale

Anne E Rosser et al. Mov Disord Clin Pract. .
No abstract available

Keywords: CAG repeat expansion; Huntington's; gene discovery.

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Conflict of interest statement

AER is supported through funding from UKRI (MR/T033428/1) and Health and Care research Wales and Horizon 2020. LJ is supported by CHDI, LoQus23 Therapeutics and the MRC (UKDRI studentship). AER and LJ serve on the European Huntington's disease network executive committee. AR and LJ hold renumerated positions on several pharmaceutical industry scientific advisory boards, as declared below.

Figures

FIG. 1
FIG. 1
(A) Members of the Huntington's Disease Collaborative Research Group (HD‐CRG), taken at a workshop in Islamorada in the late 1980s (kindly supplied by Professor G Bates). (B) The discovery of the gene for HD has led to multiple potential disease‐modifying targets, such as targeting DNA repair proteins with the aim of reducing CAG expansion in the brain, and strategies to reduce levels of huntingtin protein, which aims to reduce the toxic effects of the mutant protein. Fig1 A supplied by Professor Gillian Bates, UCL, London UK.
See this image and copyright information in PMC

References

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