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Case Reports
. 2022 Mar 24:28:e01485.
doi: 10.1016/j.idcr.2022.e01485. eCollection 2022.

Primary herpes simplex virus type 1 infection with acute liver failure in solid organ transplantation: Report of three cases and review

Carolt Arana  1 , Frederic Cofan  1 , Pablo Ruiz  2 , Evelyn Hermida  1 , Javier Fernández  2 , Jordi Colmenero  2 , Xavier Forns  2 , Laia Escude  2 , David Cucchiari  1 , Asunción Moreno  3 , Marta Bodro  3 , Sabina Herrera  3 , Camino Rodriguez  4 , David Paredes  4 , Fritz Diekmann  1
Affiliations
Case Reports

Primary herpes simplex virus type 1 infection with acute liver failure in solid organ transplantation: Report of three cases and review

Carolt Arana et al. IDCases. .

Abstract

Herpes virus infections is not uncommon in solid organ transplantation patients. We report 3 cases with primary Herpes simplex virus type-1 (HSV1) infection with acute liver failure (ALF). This is a rare and potentially fatal entity that could be a donor-derived infection. Although the initial clinical presentation is non-specific, it should be considered as a differential diagnosis in HSV-negative serology patients with liver failure and empirical treatment must be started in combination with a drastic reduction of immunosuppression. A strategy of HSV prophylaxis for pre-transplant HSV seronegative patients must be stablished in order to reduce the risk of clinical disease.

Keywords: Donor derived transmitted disease; HSV-1; Herpes simplex virus hepatitis; SOT; Transplantation.

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Conflict of interest statement

The authors don’t have conflicts of interest, on the publication of this paper.

Figures

Fig. 1
Fig. 1
HSV prophylaxis algorithm for pre-transplant HSV seronegative patients (*) Dose for GFR> 50 ml / min. Adjust dose with kidney failure.
See this image and copyright information in PMC

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