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Randomized Controlled Trial
. 2022 Apr 7;23(1):267.
doi: 10.1186/s13063-022-06199-8.

Evaluation of the effect of targeted Mass Drug Administration and Reactive Case Detection on malaria transmission and elimination in Eastern Hararghe zone, Oromia, Ethiopia: a cluster randomized control trial

Semira Abdelmenan  1 , Hiwot Teka  2 , Jimee Hwang  3 , Samuel Girma  2 , Sheleme Chibsa  2 , Eric Tongren  4 , Matthew Murphy  3 , Mebrahatom Haile  5 , Dereje Dillu  5 , Jawar Kassim  6 , Sinknesh Behaksra  7 , Fitsum G Tadesse  7 , Joshua Yukich  8 , Yemane Berhane  9 , Alemayehu Worku  9 , Joseph Keating  8 , Ayele Zewde  9 , Endalamaw Gadisa  7
Affiliations
Randomized Controlled Trial

Evaluation of the effect of targeted Mass Drug Administration and Reactive Case Detection on malaria transmission and elimination in Eastern Hararghe zone, Oromia, Ethiopia: a cluster randomized control trial

Semira Abdelmenan et al. Trials. .

Abstract

Background: Reactive and proactive case detection measures are widely implemented by national malaria elimination programs globally. Ethiopia decided to include Reactive Case Detection (RCD) and targeted Mass Drug Administration (tMDA) approaches as part of their elimination strategy along with rigorous evaluation. The purpose of this study is to compare the impact of RCD and tMDA on malaria elimination over the 2-year study period, by looking at the annual parasite incidence before and after the intervention.

Methods: The study will be conducted in the East Hararghe zone of Ethiopia. Malaria transmission in the area is low to moderate. This study will deploy a community-based, three-arm, cluster-randomized control trial implemented over 2 years. Forty-eight clusters (16 clusters per arm) will be selected based on the annual number of confirmed malaria cases seen in the cluster. All clusters will receive the current standard of care in terms of malaria elimination interventions provided by the national malaria control program. In addition, following the identification of malaria parasite infection, individuals who reside within a 100-m radius of the index case will receive a diagnosis for malaria and treatment if positive in the RCD arm or presumptive treatment in the tMDA arm. The primary effectiveness endpoint will be measured at baseline and endline for each intervention arm and compared to the control arm using a difference in difference approach.

Discussion: This randomized controlled trial will provide evidence of the impact of the proposed intervention approaches for malaria elimination.

Trial registration: ClinicalTrials.gov NCT04241705 . Registration date: January 27, 2020.

Keywords: Cluster randomized controlled trial; Ethiopia; Malaria; Reactive case detection; Targeted mass drug administration.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Randomization procedure, interventions, and evaluation timeline
Fig. 2
Fig. 2
Malaria transmission settings of woredas in East Hararghe zone, Oromia regional state, Ethiopia, 2017
See this image and copyright information in PMC

References

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