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Comment
. 2022 Apr 7;7(1):118.
doi: 10.1038/s41392-022-00965-5.

Omicron: Master of immune evasion maintains robust ACE2 binding

Markus Hoffmann  1   2 , Lu Zhang  1   2 , Stefan Pöhlmann  3   4
Affiliations
Comment

Omicron: Master of immune evasion maintains robust ACE2 binding

Markus Hoffmann et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
ACE2 interactions and resistance against antibody-mediated neutralization of the Omicron spike protein. a Left panel: Model of the trimeric SARS-CoV-2 spike protein bound to ACE2 (red). Right panel: Close-up on the binding interface of the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (violet) and ACE2 (green). RBD residues that are mutated in the Omicron variant sublineage (BA.1) are highlighted (red). b Individual and combined impact of Omicron-specific RBD mutations. Omicron residues that establish new interactions with ACE2 are highlighted (gray). c Relative ACE2 binding by the spike proteins of wild-type (WT) SARS-CoV-2 and SARS-CoV-2 variants Delta and Omicron. d Convalescent and vaccinee sera exhibit low neutralization potency against the Omicron variant. e The Omicron variant is resistant against most monoclonal antibodies (mAbs) that neutralize WT SARS-CoV-2 with high potency.
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Comment on

References

    1. Mannar, D. et al. SARS-CoV-2 Omicron variant: antibody evasion and cryo-EM structure of spike protein-ACE2 complex. Science10.1126/science.abn7760 (2022). - PMC - PubMed
    1. Zhang, J. et al. Structural and functional impact by SARS-CoV-2 Omicron spike mutations. bioRxiv10.1101/2022.01.11.47592 (2022). - PMC - PubMed
    1. McCallum, M. et al. Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement. Science10.1126/science.abn8652 (2022). - PMC - PubMed
    1. Hoffmann M, et al. The Omicron variant is highly resistant against antibody-mediated neutralization: implications for control of the COVID-19 pandemic. Cell. 2022;185:447–456.e411. doi: 10.1016/j.cell.2021.12.032. - DOI - PMC - PubMed
    1. Lamers, M. M. et al. SARS-CoV-2 Omicron efficiently infects human airway, but not alveolar epithelium. bioRxiv10.1101/2022.01.19.476898 (2022).

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